Background
and Aim: Tumor
associated tissue eosinophilia (TATE) is observed in several types of neoplasms,however, its relation with cancers such as
Squamous Cell Carcinoma (SCC) which is the most common malignancy of head and
neck has not been identified This study aims to evaluate the relationship
between TATE and histologic grading of head and neck SCC (HNSCC) by Luna’s
histochemical staining.
Materials
and Methods: In this descriptive study, 67 slides of
4μ HNSCC tissue sections were stained with hematoxylin and eosin. Samples were
reviewed to evaluate histologic grading and then were divided into three groups
as follows: Well-Differentiated, Moderately-Differentiated and
Poorly-Differentiated. Eosinophil infiltration in tumor was assessed with
Luna’s histochemical staining technique and eosinophils were counted and
classified as follows: none (0), low (1-4), moderate (5-19), high (≥20). They
were randomly evaluated per 10 microscopic fields. Kruskal-Wallis test and
Spearman correlation coefficient were used to analyze the results.
Results:Tissue eosinophilia was
found to be zero in only one case (1.5%)whereas in other 66 patients (98.5%) it was reported to be positive. The
mean±SD number of counted eosinophil cells was 4.7±5.4. There was a significant
correlation between the degree of histopathologic grade and TATE (P=0.04), but
no significant relationship was detected between TATE and age, sex and lesion
location.
Conclusion:
Tissue eosinophilia in Poorly-Differentiated group of HNSCC patients was lower
than the other two groups, but no relationship associated with other
clinicopathologic factors was found.
Rahrotaban S, Jolehar M, Khatibi A. Tissue Eosinophilia in Head and Neck Squamous Cell Carcinoma. J Res Dent Sci 2012; 9 (3) URL: http://jrds.ir/article-1-460-en.html