Abstract :

  Background and Aim: p53 is one of the most recognizing biomarkers has been studied in oral SCC and other human malignancies. This is a review study to assess the clinical relation between prognosis value of p53 protein and determining clinicopathological factors such as recurrence,patient survival, extent of local invasion, metastasis, tumor size and cell differentiation as well as other features of OSCC.

  Materials and Methods : A literature review articles using the databases such as Medline, Cochrane Library, Google scholar, Iran Medex, Scopus, Embase, and Science Citation Index between 1995-2012 years,by keywords, Scc associated with prognosis, clinical outcome, and p53, which contains 30articles had been collected..At the next step, the articles were divided into two groups of before and after year of 2005 due to achieving more obvious results . The positive and negative relationship between p53 and prognosis of OSCC were analysed statistically by chi-square test.

  Results: After statistical analysis, it would be clear that 83.3% of articles related to after 2005, confirmed the relationship of p53 expression and poor prognosis of OSCC vs this point was only 38.9% in the articles related to before 2005. The differences were statistically significant.(p<0.02)

  Conclusion : It seems that, majority of recent studies confirmed the relationship of p53 expression and poor prognosis of OSCC. So, this marker can be used for evaluation of prognosis in OSCC patients.