Abstract :

  Introduction: The origin of metastatic Melanoma is unknown in approximately 5-10% of the patients. Various suggestions have been made for the primary origin of this lesion. In this article, a rare case of metastatic Melanoma is reported in submandibular area.

  Case presentation: A 20 year-old woman was referred with a cystic lump in the submandibular area. She reported a pigmented macule on her lip that was completely regressed at the time of clinical evaluation. Excisional biopsy showed the lesion to be Metastatic Melanoma. The diagnosis was confirmed by Immuno-histochemcial staining for HMB45 and S100 markers. The patient is reported to be free of disease in four-year follow up based on the clinical as well as Para clinical evaluation.

  Conclusion : Total excision of the solitary lesion is suggested in patients with metastatic Melanoma with unknown origin and regression of the primary lesion.