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:: Volume 20, Issue 2 (jrds 2023) ::
J Res Dent Sci 2023, 20(2): 25-34 Back to browse issues page
Comparison of EGFR (Epithelial Growth Factor Receptor) expression as a protein marker in Oral Erosive & Reticular Lichen Planus and Oral Epithelial Dysplasia
Forooz Keshani , Fateme Fallah , Fateme Mosayebi samani , Atefe Esfandpour , Neda Kargahi *
dental faculty
Abstract:   (1026 Views)
Background and Aim: the malignant transformation of types of erosive and atrophic oral lichen planus has been further studied. Epithelial growth factor receptor is an intramembranous receptor which is related to carcinogenesis. The aim of the present study was to determine the expression of EGFR marker in erosive and reticular oral lichen planus and oral epithelial dysplasia.
Materials and Methods: In this cross-sectional descriptive-analytical study, after specimens selection(20 erosive oral lichen planus(with no dysplasia), 20 reticular, 20 oral epithelial dysplasia lesion, 10 Inflammatory Fibrous Hyperplasia (control group)) Immunohistochemical staining with EGFR antibody kit was performed and mean percentage of stained cells with EGFR Marker, pattern of staining, intensity of staining and stained-cell place  in each sample was investigated simultaneously   by two oral pathologist. finally, Data obtained were analyzed using SPSS software (VERSION 20) and Kruskal–Wallis, Mann–Whitney and Fisher tests (Pvalue<0.05).
Results: There was no significant difference between the mean percentage of stained cells in erosive and reticular oral lichen planus(Pvalue=0.213).while erosive lichen planus and oral epithelial dysplasia presented significant difference in this regard(Pvalue=0.017). There was no significant difference between the frequency distribution of staining  pattern in groups(Pvalue=0.16)also there was no significant difference between the intensity of staining and the stained-cell place in 4 groups(Pvalue=0.19 , Pvalue=0.90).
Conclusion: The expression of EGFR in patients with oral erosive lichen planus and oral epithelial dysplasia was higher than patients with oral reticular lichen planus and control group and it probably shows the higher potential of dysplastic changes in erosive lichen planus than reticular.
 
Keywords:  Epithelial Growth Factor receptor (EGFR), Oral Erosive Lichen Planus, Oral Reticular Lichen Planus, Oral Epithelial Dysplasia
Full-Text [PDF 880 kb]   (634 Downloads)    
Type of Study: original article | Subject: oral patho
References
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2. 2Adorno-Farias D, Badilla SM, Vidal GP, Fernandez-Ramires R. Epidermal Growth Factor Receptor (EGFR) is Overexpressed in Both Dysplasia and Neoplastic Oral Diseases. OMPJ 2022;13(2):73-78
3. Tan Y, Yan B, Xue L, Li Y, Luo X, Ji P. Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for the diagnosis of the oral squamous cell carcinoma. Lipids Health Dis. 2017;16(1):73 [DOI:10.1186/s12944-017-0465-y] [PMID] [PMCID]
4. Bakhtiari S, Mortazavi H, Mehdipour M, Jafarian N, Ranjbari N, Rahmani S. Frequency of Head and Neck Squamous Cell Carcinomas and Related Variables in Southern Iran (Ahvaz City): 10-Year Retrospective Study. Asian Pac. J. Cancer Prev. 2017;18(2):375-9
5. Yang Q, Guo B, Sun H, Zhang J, Liu S, Hexige S, et al. Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing. Oncol. Rep. 2017;37(4):2355-65 [DOI:10.3892/or.2017.5487] [PMID]
6. Lorini L, Bescós Atín C, Thavaraj S, Müller-Richter U, Alberola Ferranti M, Pamias Romero J, et al. Overview of oral potentially malignant disorders: from risk factors to specific therapies. Cancers 2021;13(15):3696 [DOI:10.3390/cancers13153696] [PMID] [PMCID]
7. Hwang JT, Gu YR, Shen M, Ralhan R, Walfish PG, Pritzker KP, et al. Individualized five-year risk assessment for oral premalignant lesion progression to cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(3):374-81 [DOI:10.1016/j.oooo.2016.11.004] [PMID]
8. Neville BW, Damm DD, Chi AC, Allen CM. Oral and maxillofacial pathology: Elsevier Health Sciences; 2016.
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10. Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L, et al. Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis.2019; 25(3):693-709.‏ [DOI:10.1111/odi.12885] [PMID]
11. Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS, et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Oral Oncol. 2017;68:92-102 [DOI:10.1016/j.oraloncology.2017.03.012] [PMID]
12. Parakh MK, Ulaganambi Sh, Ashifa N, Premkumar R, Jain Amit L. Oral potentially malignant disorders. Eur. J. Cancer Prev. 2020. 29(1): 65-72 [DOI:10.1097/CEJ.0000000000000510] [PMID]
13. Tsushima F, Sakurai J, Uesugi A, Oikawa Y, Ohsako T, Mochizuki Y, et al. Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients. BMC Oral Health2021;21(1):1-9.‏ [DOI:10.1186/s12903-021-01652-7] [PMID]
14. Lingam HT, Swetha P, Manyam R. Immunohistochemical evaluation of survivin in oral lichen planus and oral squamous cell carcinoma - a retrospective study. Med Pharm Rep. 2021;94(3):341-347. [DOI:10.15386/mpr-1746] [PMID] [PMCID]
15. Moosavi MS, Tavakol F. Literature review of cancer stem cells in oral lichen planus: a premalignant lesion. Stem Cell Investig 2021;8:25. [DOI:10.21037/sci-2020-049] [PMID] [PMCID]
16. Roy A. Molecular docking analysis of compounds from Andrographis paniculata with EGFR. Bioinformation. 2021;17(1):23-8 [DOI:10.6026/97320630017023] [PMID] [PMCID]
17. Cheng W-L, Feng P-H, Lee K-Y, Chen K-Y, Sun W-L, Van Hiep N, Luo C-S, Wu S-M. The role of EREG/EGFR pathway in tumor progression. Int J Mol Sci. 2021;22(23):12828 [DOI:10.3390/ijms222312828] [PMID] [PMCID]
18. Sabbah DA, Hajjo R, Sweidan K. Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors. Curr Top Med Chem. 2020;20(10):815-834 [DOI:10.2174/1568026620666200303123102] [PMID]
19. Baba Y, Maeda T, Suzuki A, Takada S, Fujii M, Kato Y. Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma. Int. J. Mol. Sci. 2017;18(2) [DOI:10.3390/ijms18020262] [PMID] [PMCID]
20. Nikitakis NG, Pentenero M, Georgaki M, Poh CF, Peterson E, Edwards P, et all. Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: current knowledge and future implications. Oral Surg Oral Med Oral Pathol Oral Radiol 2018;125(6)650-669 [DOI:10.1016/j.oooo.2018.03.012] [PMID]
21. Tseng YK, Chen CF, Shu CW, Lee CH, Chou YT, Li YJ, et al. Effect of EGFR on SQSTM1 Expression in Malignancy and Tumor Progression of Oral Squamous Cell Carcinoma. Int. J. Mol. Sci.2021;22(22): 12226. [DOI:10.3390/ijms222212226] [PMID] [PMCID]
22. Bhattacharyya S, Ray S, Saha D, Mustafi SM, Alam N, Sarkar A, et al. Chewing tobacco may act as a risk factor for dysplastic transformation of squamous cells in Oral leukoplakia- A cytochemistry based approach. Pathol. Res. Pract.2021; 218: 153287 [DOI:10.1016/j.prp.2020.153287] [PMID]
23. Shorghashti R, Sadri D, Farhadi S. Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst. J Res Dent Sci. 2020;17(2):127-136 [DOI:10.29252/jrds.17.2.127]
24. Ries J, Vairaktaris E, Agaimy A, Bechtold M, Gorecki P, Neukam FW, et al. The relevance of EGFR overexpression for the prediction of the malignant transformation of oral leukoplakia. Oncol. Rep. 2013;30(3):1149-56 [DOI:10.3892/or.2013.2545] [PMID]
25. Ribeiro M, Teixeira SR, Azevedo MN, Fraga AC, Jr., Gontijo AP, Vencio EF. Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma. Tumour Biol . 2017;39(4) [DOI:10.1177/1010428317695527] [PMID]
26. González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, Ayén Á, González-Ruiz L, Ruiz-Ávila I, Ramos-García P. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper. Med Oral Patol Oral Cir Bucal. 2021;26(4):e541-e548 [DOI:10.4317/medoral.24610] [PMID] [PMCID]
27. Zotti F, Nocini R, Capocasale G, Bertossi D, Fior A, Peretti M, Manfrin E, Albanese M. Oral Lichen Planus: risk factors of malignant transformation and follow up. Ten years retrospective study. J Clin Exp Dent 2021;13(7):630-6 [DOI:10.4317/jced.57688] [PMID] [PMCID]
28. Mutafchieva MZ, Draganova-Filipova MN, Zagorchev PI, Tomov GT.Oral Lichen Planus - Known and Unknown: a Review. Folia Med (Plovdiv) 2018;60(4):528-535 [DOI:10.2478/folmed-2018-0017] [PMID]
29. Kumagai K, Horikawa T, Gotoh A, Yamane S, Yamada H, Kobayashi H, et al. Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(6):748-54. [DOI:10.1016/j.tripleo.2010.06.022] [PMID]
30. Cortes-Ramirez DA, Rodriguez-Tojo MJ, Coca-Meneses JC, Marichalar-Mendia X, Aguirre-Urizar JM. Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease. Med Oral Patol Oral Cir Bucal. 2014;19(5):451-8. [DOI:10.4317/medoral.19452] [PMID] [PMCID]
31. Moorthy A, Venugopal DC, Shyamsundar V, Madhavan Y, Ravindran S, Kuppuloganathan M, et al. Identification of EGFR as a Biomarker in Saliva and Buccal Cells from Oral Submucous Fibrosis Patients-A Baseline Study. Diagnostics 2022;12(8),1935 [DOI:10.3390/diagnostics12081935] [PMID] [PMCID]
32. 2Adorno-Farias D, Badilla SM, Vidal GP, Fernandez-Ramires R. Epidermal Growth Factor Receptor (EGFR) is Overexpressed in Both Dysplasia and Neoplastic Oral Diseases. OMPJ 2022;13(2):73-78
33. Tan Y, Yan B, Xue L, Li Y, Luo X, Ji P. Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for the diagnosis of the oral squamous cell carcinoma. Lipids Health Dis. 2017;16(1):73 [DOI:10.1186/s12944-017-0465-y] [PMID] [PMCID]
34. Bakhtiari S, Mortazavi H, Mehdipour M, Jafarian N, Ranjbari N, Rahmani S. Frequency of Head and Neck Squamous Cell Carcinomas and Related Variables in Southern Iran (Ahvaz City): 10-Year Retrospective Study. Asian Pac. J. Cancer Prev. 2017;18(2):375-9
35. Yang Q, Guo B, Sun H, Zhang J, Liu S, Hexige S, et al. Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing. Oncol. Rep. 2017;37(4):2355-65 [DOI:10.3892/or.2017.5487] [PMID]
36. Lorini L, Bescós Atín C, Thavaraj S, Müller-Richter U, Alberola Ferranti M, Pamias Romero J, et al. Overview of oral potentially malignant disorders: from risk factors to specific therapies. Cancers 2021;13(15):3696 [DOI:10.3390/cancers13153696] [PMID] [PMCID]
37. Hwang JT, Gu YR, Shen M, Ralhan R, Walfish PG, Pritzker KP, et al. Individualized five-year risk assessment for oral premalignant lesion progression to cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(3):374-81 [DOI:10.1016/j.oooo.2016.11.004] [PMID]
38. Neville BW, Damm DD, Chi AC, Allen CM. Oral and maxillofacial pathology: Elsevier Health Sciences; 2016.
39. Ramos‐García P, González‐Moles MÁ, Warnakulasuriya S. Oral cancer development in lichen planus and related conditions-3.0 evidence level: a systematic review of systematic reviews. Oral Dis.2021;27(8):1919-1935.‏ [DOI:10.1111/odi.13812] [PMID]
40. Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L, et al. Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis.2019; 25(3):693-709.‏ [DOI:10.1111/odi.12885] [PMID]
41. Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS, et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Oral Oncol. 2017;68:92-102 [DOI:10.1016/j.oraloncology.2017.03.012] [PMID]
42. Parakh MK, Ulaganambi Sh, Ashifa N, Premkumar R, Jain Amit L. Oral potentially malignant disorders. Eur. J. Cancer Prev. 2020. 29(1): 65-72 [DOI:10.1097/CEJ.0000000000000510] [PMID]
43. Tsushima F, Sakurai J, Uesugi A, Oikawa Y, Ohsako T, Mochizuki Y, et al. Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients. BMC Oral Health2021;21(1):1-9.‏ [DOI:10.1186/s12903-021-01652-7] [PMID] [PMCID]
44. Lingam HT, Swetha P, Manyam R. Immunohistochemical evaluation of survivin in oral lichen planus and oral squamous cell carcinoma - a retrospective study. Med Pharm Rep. 2021;94(3):341-347. [DOI:10.15386/mpr-1746] [PMID] [PMCID]
45. Moosavi MS, Tavakol F. Literature review of cancer stem cells in oral lichen planus: a premalignant lesion. Stem Cell Investig 2021;8:25. [DOI:10.21037/sci-2020-049] [PMID] [PMCID]
46. Roy A. Molecular docking analysis of compounds from Andrographis paniculata with EGFR. Bioinformation. 2021;17(1):23-8 [DOI:10.6026/97320630017023] [PMID] [PMCID]
47. Cheng W-L, Feng P-H, Lee K-Y, Chen K-Y, Sun W-L, Van Hiep N, Luo C-S, Wu S-M. The role of EREG/EGFR pathway in tumor progression. Int J Mol Sci. 2021;22(23):12828 [DOI:10.3390/ijms222312828] [PMID] [PMCID]
48. Sabbah DA, Hajjo R, Sweidan K. Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors. Curr Top Med Chem. 2020;20(10):815-834 [DOI:10.2174/1568026620666200303123102] [PMID]
49. Baba Y, Maeda T, Suzuki A, Takada S, Fujii M, Kato Y. Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma. Int. J. Mol. Sci. 2017;18(2) [DOI:10.3390/ijms18020262] [PMID] [PMCID]
50. Nikitakis NG, Pentenero M, Georgaki M, Poh CF, Peterson E, Edwards P, et all. Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: current knowledge and future implications. Oral Surg Oral Med Oral Pathol Oral Radiol 2018;125(6)650-669 [DOI:10.1016/j.oooo.2018.03.012] [PMID]
51. Tseng YK, Chen CF, Shu CW, Lee CH, Chou YT, Li YJ, et al. Effect of EGFR on SQSTM1 Expression in Malignancy and Tumor Progression of Oral Squamous Cell Carcinoma. Int. J. Mol. Sci.2021;22(22): 12226. [DOI:10.3390/ijms222212226] [PMID] [PMCID]
52. Bhattacharyya S, Ray S, Saha D, Mustafi SM, Alam N, Sarkar A, et al. Chewing tobacco may act as a risk factor for dysplastic transformation of squamous cells in Oral leukoplakia- A cytochemistry based approach. Pathol. Res. Pract.2021; 218: 153287 [DOI:10.1016/j.prp.2020.153287] [PMID]
53. Shorghashti R, Sadri D, Farhadi S. Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst. J Res Dent Sci. 2020;17(2):127-136 [DOI:10.29252/jrds.17.2.127]
54. Ries J, Vairaktaris E, Agaimy A, Bechtold M, Gorecki P, Neukam FW, et al. The relevance of EGFR overexpression for the prediction of the malignant transformation of oral leukoplakia. Oncol. Rep. 2013;30(3):1149-56 [DOI:10.3892/or.2013.2545] [PMID]
55. Ribeiro M, Teixeira SR, Azevedo MN, Fraga AC, Jr., Gontijo AP, Vencio EF. Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma. Tumour Biol . 2017;39(4) [DOI:10.1177/1010428317695527] [PMID]
56. González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, Ayén Á, González-Ruiz L, Ruiz-Ávila I, Ramos-García P. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper. Med Oral Patol Oral Cir Bucal. 2021;26(4):e541-e548 [DOI:10.4317/medoral.24610] [PMID] [PMCID]
57. Zotti F, Nocini R, Capocasale G, Bertossi D, Fior A, Peretti M, Manfrin E, Albanese M. Oral Lichen Planus: risk factors of malignant transformation and follow up. Ten years retrospective study. J Clin Exp Dent 2021;13(7):630-6 [DOI:10.4317/jced.57688] [PMID] [PMCID]
58. Mutafchieva MZ, Draganova-Filipova MN, Zagorchev PI, Tomov GT.Oral Lichen Planus - Known and Unknown: a Review. Folia Med (Plovdiv) 2018;60(4):528-535 [DOI:10.2478/folmed-2018-0017] [PMID]
59. Kumagai K, Horikawa T, Gotoh A, Yamane S, Yamada H, Kobayashi H, et al. Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(6):748-54. [DOI:10.1016/j.tripleo.2010.06.022] [PMID]
60. Cortes-Ramirez DA, Rodriguez-Tojo MJ, Coca-Meneses JC, Marichalar-Mendia X, Aguirre-Urizar JM. Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease. Med Oral Patol Oral Cir Bucal. 2014;19(5):451-8. [DOI:10.4317/medoral.19452] [PMID] [PMCID]
61. Moorthy A, Venugopal DC, Shyamsundar V, Madhavan Y, Ravindran S, Kuppuloganathan M, et al. Identification of EGFR as a Biomarker in Saliva and Buccal Cells from Oral Submucous Fibrosis Patients-A Baseline Study. Diagnostics 2022;12(8),1935 [DOI:10.3390/diagnostics12081935] [PMID] [PMCID]
62. 2Adorno-Farias D, Badilla SM, Vidal GP, Fernandez-Ramires R. Epidermal Growth Factor Receptor (EGFR) is Overexpressed in Both Dysplasia and Neoplastic Oral Diseases. OMPJ 2022;13(2):73-78
63. Tan Y, Yan B, Xue L, Li Y, Luo X, Ji P. Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for the diagnosis of the oral squamous cell carcinoma. Lipids Health Dis. 2017;16(1):73 [DOI:10.1186/s12944-017-0465-y] [PMID]
64. Bakhtiari S, Mortazavi H, Mehdipour M, Jafarian N, Ranjbari N, Rahmani S. Frequency of Head and Neck Squamous Cell Carcinomas and Related Variables in Southern Iran (Ahvaz City): 10-Year Retrospective Study. Asian Pac. J. Cancer Prev. 2017;18(2):375-9
65. Yang Q, Guo B, Sun H, Zhang J, Liu S, Hexige S, et al. Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing. Oncol. Rep. 2017;37(4):2355-65 [DOI:10.3892/or.2017.5487] [PMID]
66. Lorini L, Bescós Atín C, Thavaraj S, Müller-Richter U, Alberola Ferranti M, Pamias Romero J, et al. Overview of oral potentially malignant disorders: from risk factors to specific therapies. Cancers 2021;13(15):3696 [DOI:10.3390/cancers13153696] [PMID] [PMCID]
67. Hwang JT, Gu YR, Shen M, Ralhan R, Walfish PG, Pritzker KP, et al. Individualized five-year risk assessment for oral premalignant lesion progression to cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(3):374-81 [DOI:10.1016/j.oooo.2016.11.004] [PMID]
68. Neville BW, Damm DD, Chi AC, Allen CM. Oral and maxillofacial pathology: Elsevier Health Sciences; 2016.
69. Ramos‐García P, González‐Moles MÁ, Warnakulasuriya S. Oral cancer development in lichen planus and related conditions-3.0 evidence level: a systematic review of systematic reviews. Oral Dis.2021;27(8):1919-1935.‏ [DOI:10.1111/odi.13812] [PMID]
70. Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L, et al. Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis.2019; 25(3):693-709.‏ [DOI:10.1111/odi.12885] [PMID]
71. Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS, et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Oral Oncol. 2017;68:92-102 [DOI:10.1016/j.oraloncology.2017.03.012] [PMID]
72. Parakh MK, Ulaganambi Sh, Ashifa N, Premkumar R, Jain Amit L. Oral potentially malignant disorders. Eur. J. Cancer Prev. 2020. 29(1): 65-72 [DOI:10.1097/CEJ.0000000000000510] [PMID]
73. Tsushima F, Sakurai J, Uesugi A, Oikawa Y, Ohsako T, Mochizuki Y, et al. Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients. BMC Oral Health2021;21(1):1-9.‏ [DOI:10.1186/s12903-021-01652-7] [PMID] [PMCID]
74. Lingam HT, Swetha P, Manyam R. Immunohistochemical evaluation of survivin in oral lichen planus and oral squamous cell carcinoma - a retrospective study. Med Pharm Rep. 2021;94(3):341-347. [DOI:10.15386/mpr-1746] [PMID] [PMCID]
75. Moosavi MS, Tavakol F. Literature review of cancer stem cells in oral lichen planus: a premalignant lesion. Stem Cell Investig 2021;8:25. [DOI:10.21037/sci-2020-049] [PMID] [PMCID]
76. Roy A. Molecular docking analysis of compounds from Andrographis paniculata with EGFR. Bioinformation. 2021;17(1):23-8 [DOI:10.6026/97320630017023] [PMID] [PMCID]
77. Cheng W-L, Feng P-H, Lee K-Y, Chen K-Y, Sun W-L, Van Hiep N, Luo C-S, Wu S-M. The role of EREG/EGFR pathway in tumor progression. Int J Mol Sci. 2021;22(23):12828 [DOI:10.3390/ijms222312828] [PMID] [PMCID]
78. Sabbah DA, Hajjo R, Sweidan K. Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors. Curr Top Med Chem. 2020;20(10):815-834 [DOI:10.2174/1568026620666200303123102] [PMID]
79. Baba Y, Maeda T, Suzuki A, Takada S, Fujii M, Kato Y. Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma. Int. J. Mol. Sci. 2017;18(2) [DOI:10.3390/ijms18020262] [PMID] [PMCID]
80. Nikitakis NG, Pentenero M, Georgaki M, Poh CF, Peterson E, Edwards P, et all. Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: current knowledge and future implications. Oral Surg Oral Med Oral Pathol Oral Radiol 2018;125(6)650-669 [DOI:10.1016/j.oooo.2018.03.012] [PMID]
81. Tseng YK, Chen CF, Shu CW, Lee CH, Chou YT, Li YJ, et al. Effect of EGFR on SQSTM1 Expression in Malignancy and Tumor Progression of Oral Squamous Cell Carcinoma. Int. J. Mol. Sci.2021;22(22): 12226. [DOI:10.3390/ijms222212226] [PMID] [PMCID]
82. Bhattacharyya S, Ray S, Saha D, Mustafi SM, Alam N, Sarkar A, et al. Chewing tobacco may act as a risk factor for dysplastic transformation of squamous cells in Oral leukoplakia- A cytochemistry based approach. Pathol. Res. Pract.2021; 218: 153287 [DOI:10.1016/j.prp.2020.153287] [PMID]
83. Shorghashti R, Sadri D, Farhadi S. Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst. J Res Dent Sci. 2020;17(2):127-136 [DOI:10.29252/jrds.17.2.127]
84. Ries J, Vairaktaris E, Agaimy A, Bechtold M, Gorecki P, Neukam FW, et al. The relevance of EGFR overexpression for the prediction of the malignant transformation of oral leukoplakia. Oncol. Rep. 2013;30(3):1149-56 [DOI:10.3892/or.2013.2545] [PMID]
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keshani F, fallah F, mosayebi samani F, esfandpour A, kargahi N. Comparison of EGFR (Epithelial Growth Factor Receptor) expression as a protein marker in Oral Erosive & Reticular Lichen Planus and Oral Epithelial Dysplasia. J Res Dent Sci 2023; 20 (2) :25-34
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مجله تحقیق در علوم دندانپزشکی Res Dent Sci
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