[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Indexing & Abstracting::
::
(CC-BY 4.0)

AWT IMAGE

Journal of Research in Dental Sciences is licensed under a "Creative Commons Attribution 4.0 International (CC-BY 4.0)"

..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
:: Volume 17, Issue 2 (jrds 2020) ::
J Res Dent Sci 2020, 17(2): 127-136 Back to browse issues page
Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst
Reihaneh Shoorgashti , Donia Sadri , Sareh Farhadi *
, dr.sfarhadi@gmail.com
Abstract:   (3042 Views)
Abstract:
Background and Aim: Compare with Dentigerous cyst, Odontogenic Keratocyst is one of exclusive developmental cyst with unique clinical and histopathologic features. Considering the determining role of epidermal growth factor receptor (EGFR) in cell proliferation and survival, and the controversial results of previous studies regarding the expression of this marker by the odontogenic cysts, this study aimed to compare the expression of EGFR marker by Dentigerous cyst (DC) and odontogenic Keratocyst (OKC) as two lesions with more common neoplastic transformation.  
Material and methods: In this experimental study, 49 specimens (23 DCs and 26 OKCs) were evaluated. Immunohistochemical staining was performed using EGFR antibody. Evaluation of EGFR expression was made regarding to Tie-JUN Li et al. So, The location of EGFR expression in the epithelial cells ( Basal layers, Suprabasal & basal , All layeres) were assessed through histopathologic sections.. Data were analyzed using the Mann-Whitney test, t-test and chi-square test.
Results: In The present Study, of 49 evaluated cases, the mean percentage of EGFR expression was 58.20±17.97% in the 23 DC and 78.05±19.27% in the 26 OKC specimens. The EGFR expression of OKC was significantly higher than DC (P=0.001). However, the Mann-Whitney test showed no significant difference regarding EGFR score (P=0.144). The chi-square test revealed no significant difference in expression of EGFR in the basal layer, basal and suprabasal layers and all layers (P=0.524).
Conclusions: The expression of EGFR marker in OKC was significantly higher than in DC, which may justify the progressive growth potential of OKC.
 
Keywords: Dentigerous cyst, Odontogenic Keratocyst, Odontogenic cyst
Full-Text [PDF 346 kb]   (1688 Downloads)    
Type of Study: original article | Subject: oral patho
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shoorgashti R, Sadri D, Farhadi S. Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst. J Res Dent Sci 2020; 17 (2) :127-136
URL: http://jrds.ir/article-1-1123-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 17, Issue 2 (jrds 2020) Back to browse issues page
مجله تحقیق در علوم دندانپزشکی Res Dent Sci
Persian site map - English site map - Created in 0.07 seconds with 38 queries by YEKTAWEB 4645