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:: Volume 17, Issue 2 (jrds 2020) ::
J Res Dent Sci 2020, 17(2): 127-136 Back to browse issues page
Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst
Reihaneh Shoorgashti Dr , Donia Sadri Dr , Sareh Farhadi Dr *
, dr.sfarhadi@gmail.com
Abstract:   (479 Views)
Abstract:
Background and Aim: Compare with Dentigerous cyst, Odontogenic Keratocyst is one of exclusive developmental cyst with unique clinical and histopathologic features. Considering the determining role of epidermal growth factor receptor (EGFR) in cell proliferation and survival, and the controversial results of previous studies regarding the expression of this marker by the odontogenic cysts, this study aimed to compare the expression of EGFR marker by Dentigerous cyst (DC) and odontogenic Keratocyst (OKC) as two lesions with more common neoplastic transformation.  
Material and methods: In this experimental study, 49 specimens (23 DCs and 26 OKCs) were evaluated. Immunohistochemical staining was performed using EGFR antibody. Evaluation of EGFR expression was made regarding to Tie-JUN Li et al. So, The location of EGFR expression in the epithelial cells ( Basal layers, Suprabasal & basal , All layeres) were assessed through histopathologic sections.. Data were analyzed using the Mann-Whitney test, t-test and chi-square test.
Results: In The present Study, of 49 evaluated cases, the mean percentage of EGFR expression was 58.20±17.97% in the 23 DC and 78.05±19.27% in the 26 OKC specimens. The EGFR expression of OKC was significantly higher than DC (P=0.001). However, the Mann-Whitney test showed no significant difference regarding EGFR score (P=0.144). The chi-square test revealed no significant difference in expression of EGFR in the basal layer, basal and suprabasal layers and all layers (P=0.524).
Conclusions: The expression of EGFR marker in OKC was significantly higher than in DC, which may justify the progressive growth potential of OKC.
 
Keywords: Dentigerous cyst, Odontogenic Keratocyst, Odontogenic cyst
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Type of Study: original article | Subject: oral patho
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Shoorgashti R, Sadri D, Farhadi S. Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst. J Res Dent Sci. 2020; 17 (2) :127-136
URL: http://jrds.ir/article-1-1123-en.html


Volume 17, Issue 2 (jrds 2020) Back to browse issues page
مجله تحقیق در علوم دندانپزشکی Res Dent Sci
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