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:: Volume 13, Issue 1 (JRDS 2016) ::
J Res Dent Sci 2016, 13(1): 36-42 Back to browse issues page
The immunohistochemical study of angiogenesis in normal oral mucosa and oral lichen planus by CD34 and DC105 markers.
N Eshghyar Dr , M Asgari Dr, S Rahrotaban Dr, R Monshizadeh Dr
Prof, Department of Oral Pathology, School of Dentistry Tehran University of Medical Sciences, Iran. , Eshghyar@yahoo.com
Abstract:   (3704 Views)

Background & aim: Oral lichen planus is a chronic inflammatory disease that its etiology has remained unknown yet, but cell mediated immunity may play a role on its pathogenesis. Angiogenesis is a major component of neoplastic and chronic inflammatory disorders but its occurrence in mucocutaneous inflammatory diseases such as OLP has not yet been proved. The aim of this study is the determination of the expression of angiogenesis markers of CD34 and CD105 in OLP and compare the rate of angiogenesis with normal mucosa.

Material and Methods: In this case-control study, thirty formalin fixed paraffin embedded OLP samples including 15 samples of reticular and 15 samples of erosive OLP were used. Immunohistochemical staining for CD34 and CD105 was done on 4 micrometer thickness sections to illustrate submucosal microvessels. Fifteen samples of normal mucosa used as positive control. Microvessel counting was done on five regions at epitheliam- connective tissue junction. The results were analyzed by one sample kolmogrov-smirnov test and post hoc test (Tamhan type) and one way Anova test  test with SPSS software 11.5.

Results: The differences of CD34 & CD105 expression were significant between two groups. (p<0.001) The  Micro vascular  density (MVD)  by CD34 was 18.16 and by CD105 was 9.96. Amount of CD34 and CD105 expression were increased with high correlation coefficient (P<0.001),( R=0.991) for both markers from normal mucosa to reticular and erosive OLP.

Conclusion: Higher expressions of CD 34 & CD 105 in OLPs compare to normal mucosa may have relation to angiogenesis in OLP lesions. This study shows potential angiogenic function in OLPs than noramal mucosa.

Keywords: Endoglin(CD105), CD34, lichen planus, immunohistochemistry
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Type of Study: original article | Subject: oral patho
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Eshghyar N, Asgari M, Rahrotaban S, Monshizadeh R. The immunohistochemical study of angiogenesis in normal oral mucosa and oral lichen planus by CD34 and DC105 markers.. J Res Dent Sci. 2016; 13 (1) :36-42
URL: http://jrds.ir/article-1-712-en.html


Volume 13, Issue 1 (JRDS 2016) Back to browse issues page
مجله تحقیق در علوم دندانپزشکی Res Dent Sci
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