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Studying the relationship between blood group antigen secretion in saliva and the development of white lesions in orthodontic patients.
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Farzaneh Golfeshan *   , AmirAli Janfada |
| Shiraz University of Medical Sciences , farzanehgolfeshan@chmail.ir |
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Abstract: (84 Views) |
Abstract
Background and Aim:White spot lesions are common complications of fixed orthodontic treatment. This study aimed to investigate the association between salivary secretor phenotype and the incidence or progression of these lesions.
Materials and methods: This observational follow-up study was conducted on 90 candidates for fixed orthodontics. Demographic data and blood groups were recorded, and unstimulated saliva samples were collected. Secretor status was determined using the agglutination inhibition test. WSLs were evaluated based on ICDAS criteria and standardized photography immediately and three months after bonding. Statistical analysis, including comparative tests (e.g., chi2, Wilcoxon, and Mann–Whitney) and binary logistic regression adjusted for confounding variables, was performed using SPSS v.27.
Results: Among 90 patients, 66 (73.3%) were secretors. The overall frequency of WSLs increased from 5.6% at baseline to 32.2% at the three-month follow-up (p < 0.001). By the end of the third month, the incidence or progression of lesions was significantly higher in non-secretors (58.3%) compared to secretors (22.7%, p < 0.05). Logistic regression identified secretor status as a significant predictor for WSLs (p = 0.009), with secretors having a 70% lower risk (OR = 0.3). Stratified analysis showed varying impacts across different blood groups.
Conclusion: Salivary non-secretor status is a significant risk factor for the development of white spot lesions during early orthodontic treatment. Identifying this phenotype can facilitate targeted preventive strategies for high-risk patients.
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Article number: 2 |
| Keywords: Secretor Status, Non-secretor, White Spot Lesions, ICDAS, Orthodontics, Saliva. |
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Full-Text [PDF 849 kb]
(89 Downloads)
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Type of Study: original article |
Subject:
Oral Medicine
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