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Investigating the effect of curcumin on nuclear changes of buccal mucosa cells caused by X-rays in CBCT imaging
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Mohsen Roshan Mehr   , Ahmadreza Talaei Pour * , Maryam Jolehar , Mohammad Javad Kharrazi Fard , Hamidreza Arefifard |
| , ar_talai@yahoo.com |
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Abstract: (122 Views) |
Abstract
Background and aim: Radiographic imaging is one of the main pillars of diagnosis in dentistry, and cone-beam computed tomography (CBCT) has widespread application due to its high accuracy. However, exposure to ionizing radiation has consistently raised concerns regarding biological and cellular effects. Therefore, identifying strategies to reduce radiation-induced damage is of particular importance. This study was conducted to investigate the effect of curcumin on nuclear changes and the repair process of buccal mucosal cells following CBCT imaging.
Materials and methods: This clinical trial was conducted in 2024 on 76 patients referred to the Department of Oral and Maxillofacial Radiology at Islamic Azad University. Participants were divided into four groups: the first group received CBCT only; the second group consumed curcumin supplementation (600 mg per day) before CBCT; the third group consumed curcumin after CBCT; and the fourth group consumed curcumin both before and after CBCT. Buccal mucosal cell sampling was performed before imaging, immediately after exposure, and ten days later, and nuclear changes were evaluated using microscopy.(P<0.001)
Results: No statistically significant differences were observed among the groups in the first and second sampling stages . However, in the third sampling stage, the micronucleus, karyolysis, and broken egg indices were significantly lower in the curcumin-receiving groups, particularly in the groups consuming curcumin after CBCT and both before and after CBCT, compared with the control group . .(P<0.001)
Conclusion: Curcumin consumption can help reduce CBCT radiation–induced nuclear damage and may play an effective protective role against the harmful effects of X-ray radiation.
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Article number: 1 |
| Keywords: Cone-Beam Computed Tomography, Curcumin, Micronucleus Tests, Buccal Mucosa, X-Rays |
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Full-Text [PDF 615 kb]
(97 Downloads)
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Type of Study: original article |
Subject:
Radiology
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