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:: Volume 9, Issue 4 (Res Dent Sci 2013) ::
J Res Dent Sci 2013, 9(4): 187-191 Back to browse issues page
Effect of the Serum Vitamin B12 and Folic Acid levels in Oral Lichen Planus
Tahere Nosratzehi, Alireza Ansari moghaddam, Fatemeh Arbabi-Kalati , Laleh Maleki, Azizollah Amiriyan
Oral Medicine Dept and Genetics of Non-communicable Disease Research Center Zahedan University of Medical Sciences, Zahedan, Iran , f_kalati@yahoo.com
Abstract:   (15991 Views)




  Background and Aim: Oral Lichen Planus (OLP) is a chronic immunologic disorder with unknown etiology. Stress and anxiety are risk factors for OLP and Vitamin B12 and Folic acid have been proved to be effective micronutrients for prevention of anxiety and depression. The purpose of this study was to assess the serum levels of Vitamin B12 and Folic acid in patients with Oral Lichen Planus


  Materials and Methods : This descriptive- analytic study selected 64 subjects (32 patients with OLP and 32 healthy samples) in whom the serum levels of folic acid and Vitamin B12 were measured with Elexis 2016 and electro-chemi-luminsence method. The results were analyzed with SPSS software (version 16) and for each individual the T-test was used for data analysis.

  Results : Serum levels of vitamin B12 in healthy subjects was 284.7±99.5 Pg/ml compared to 288± 165.7 Pg/ml in patients with oral Lichen Planus. Serum levels of folic acid in healthy subjects was 12.4±4.2 ng / ml whereas in patients with OLP it was found to be 9.45±4 ng / ml. The T-Test showed that there is no statistically significant difference in B12 levels between healthy subjects and patients with OLP.(P=0.93) However, the serum levels for Folic Acid was significantly lower in patients with OLP compared to healthy subjects. (p=0.03).

  Conclusion: Folic acid deficiency may have a role in the pathogenesis of OLP. More studies are needed to prove such relation.


Keywords: Oral Lichen Plnus, Folic Acid, Vitamin B12
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Nosratzehi T, Ansari moghaddam A, Arbabi-Kalati F, Maleki L, Amiriyan A. Effect of the Serum Vitamin B12 and Folic Acid levels in Oral Lichen Planus. J Res Dent Sci. 2013; 9 (4) :187-191
URL: http://jrds.ir/article-1-316-en.html

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Volume 9, Issue 4 (Res Dent Sci 2013) Back to browse issues page
مجله تحقیق در علوم دندانپزشکی Res Dent Sci
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