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Background and Aim: Mouthwashes are one of the tools used to reduce decay. Fluorin total mouthwash is a new mouthwash, so far no research has been done on its effect on streptococcus mutans.
Materials and Methods: In this study, the diameter of growth inhibition zone for streptococcus mutans bacteria was compared between fluorin total and chlorhexidine mouthwash. First, we cultured the bacteria on blood agar and incubated for 24 hours at 37^° C. Then, we cultivated it on 21 blood agar plates. We randomly put one chlorhexidine disk on 10 plates and one fluorin total disk on other 10 plates. We also placed antibiogram disk and a blank disk without mouthwash on 1 plate. We placed the plates at 37° C for 24 to 48 hours into the incubator and then measured the growth inhibition zone.
Results: The growth inhibition zone in the chlorhexidine and fluorin total group was 15.4 mm and 11.4 mm, respectively, which was 4mm higher in the chlorhexidine group,which is statistically significant.
Conclusion: Due to the complications of chlorhexidine mouthwash, this mouthwash cannot be used on a daily basis. It seems that fluorin total mouthwash can be used as an auxiliary method for those who are at high risk of decay.

 

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Abstract
Background and aim: Candida albicans is the main fungus in human mucous membranes that causes superficial and life-threatening infections in immunocompromised individuals as an opportunistic pathogen. Honey has been used to treat many systemic diseases such as asthma, gastrointestinal diseases and skin diseases such as wounds, injuries and eczema. The aim of this in vitro study was to investigate the antifungal effect of honey on Candida albicans.
Materials and Methods: In this experimental and in-vitro study, 47 plates containing Candida albicans were examined. Samples of natural honey were prepared from Khoy, Salmanshahr from local beekeepers and commercial samples from Mahram company. Volume percentages of 20,40,60,80,95 were prepared from all honey samples. Cup-plate technique and Agar diffusion method and Sabourod dextrose agar (SDA) culture medium were used to investigate the growth inhibition and diameter of growth inhibition zone. The obtained results (diameter of growth inhibition zone) were analyzed after three cultures by SPSS 24 and one-way ANOVA statistical method. Tukey test was also used for pairwise comparison, P<0/05 was considered significant .
Results: All types of honey in maximum concentrations (95%) inhibited the growth of Candida and only Salmanshahr honey  in a concentration of 80% inhibited the growth of Candida albicans. There was a significant difference in inhibited of Candida albicans between groups with P = 0.03. Comparing Salmanshahr honey with Mahram honey with P = 0.022, a significant difference was obtained and Salmanshahr honey significantly inhibited Candida. There was no significant difference between Khoy honey and Mehram honey with P = 0.27.
Conclusion: The findings of this study showed that honey in high concentrations can have an inhibitory effect on the growth of Candida albicans and can be used as a safe antifungal treatment in patients.