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:: دوره 20، شماره 2 - ( فصلنامه تحقيق در علوم دندانپزشكي تابستان 1402 ) ::
جلد 20 شماره 2 صفحات 34-25 برگشت به فهرست نسخه ها
مقایسه ی بروز گیرنده فاکتور رشد اپیتلیالی EGFR در ضایعات لیکن پلان دهانی اروزیو ، رتیکولر و دیس پلازی اپیتلیالی
فروز کشانی ، فاطمه فلاح ، فاطمه مسیبی سامانی ، عاطفه اسفندپور ، ندا کارگهی*
گروه آموزشی آسیب شناسی فک و دهان و صورت ، مرکز تحقیقات دندانپزشکی ، پژوهشکده علوم دندانپزشکی، دانشکده دندانپزشکی ، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
چکیده:   (892 مشاهده)
 سابقه و هدف: احتمال پیشرفت به بدخیمی انواع اروزیو و آتروفیک لیکن پلان نسبت به انواع دیگر مورد بحث است. (EGFR) یکی از عواملی  است که با تومورزایی در ارتباط است. در این مطالعه هدف، بررسی بروز نشانگر EGFR  در بیماری لیکن پلان دهانی اروزیو ورتیکولرو ضایعات دیس پلازی اپی تلیوم دهانی بود.
مواد و روش ها: در این  مطالعه ی توصیفی- تحلیلی ,پس از انتخاب نمونه ها( 20 لیکن پلان دهانی اروزیو(فاقد دیسپلازی)  ،20 نمونه لیکن پلان رتیکولر، 20 ضایعه دیسپلاستیک ، 10 نمونه هایپرپلازی فیبروزه ی التهابی (گروه کنترل) با نشانگر EGFR رنگ آمیزی و میزان درصد سلول های رنگ گرفته ، الگو، شدت رنگ  ومحل  رنگ پذیری در لایه های مختلف اپی تلیوم توسط دوپاتولوژیست دهان، همزمان مورد بررسی قرار گرفت. در نهایت داده ها توسط نرم افزار SPSS 20 version، روش های آماری توصیفی و آزمونهای کروسکالواریس، من ویتنی و فیشرتحلیل شدند.
یافته ها: میزان سلولهای رنگ پذیرفته بین لیکن پلان اروزیو و لیکن پلان رتیکولر تفاوت معناداری نداشت (213/0 P=) در حالیکه بین میزان لیکن پلان اروزیو و دیسپلازی دهانی تفاوت معناداری وجود داشت  (017/0P=) در  فراوانی الگوی رنگ پذیری میان گروه های مختلف تفاوت معناداری وجود نداشت. (16/0P=). و نیز تفاوت معنی داری بین شدت و محل رنگ پذیری در چهار گروه نبود(به ترتیب (19/0 P= و 90/0  P=  ).
نتیجه گیری:  بروز  EGFRدر  لیکن پلان دهانی اروزیو وضایعات دیس پلاستیک دهان نسبت به گروه لیکن پلان دهانی رتیکولر وکنترل کمی بالاتر بوده و احتمالا میتواند نشاندهنده پتانسیل تغییرات دیس پلاستیک بیشتر در اروزیو نسبت به رتیکولر باشد.
واژه‌های کلیدی: کلید واژه­ها: گیرنده ی فاکتور رشد اپیتلیالی، بیماری لیکن پلان دهانی اروزیو، بیماری لیکن پلان دهانی  رتیکولر، دیس پلازی اپیتلیومی دهانی
متن کامل [PDF 880 kb]   (536 دریافت)    
نوع مطالعه: مطالعه اصیل | موضوع مقاله: اورال پاتولوژی
فهرست منابع
1. Moorthy A, Venugopal DC, Shyamsundar V, Madhavan Y, Ravindran S, Kuppuloganathan M, et al. Identification of EGFR as a Biomarker in Saliva and Buccal Cells from Oral Submucous Fibrosis Patients-A Baseline Study. Diagnostics 2022;12(8),1935 [DOI:10.3390/diagnostics12081935] [PMID] [PMCID]
2. 2Adorno-Farias D, Badilla SM, Vidal GP, Fernandez-Ramires R. Epidermal Growth Factor Receptor (EGFR) is Overexpressed in Both Dysplasia and Neoplastic Oral Diseases. OMPJ 2022;13(2):73-78
3. Tan Y, Yan B, Xue L, Li Y, Luo X, Ji P. Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for the diagnosis of the oral squamous cell carcinoma. Lipids Health Dis. 2017;16(1):73 [DOI:10.1186/s12944-017-0465-y] [PMID] [PMCID]
4. Bakhtiari S, Mortazavi H, Mehdipour M, Jafarian N, Ranjbari N, Rahmani S. Frequency of Head and Neck Squamous Cell Carcinomas and Related Variables in Southern Iran (Ahvaz City): 10-Year Retrospective Study. Asian Pac. J. Cancer Prev. 2017;18(2):375-9
5. Yang Q, Guo B, Sun H, Zhang J, Liu S, Hexige S, et al. Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing. Oncol. Rep. 2017;37(4):2355-65 [DOI:10.3892/or.2017.5487] [PMID]
6. Lorini L, Bescós Atín C, Thavaraj S, Müller-Richter U, Alberola Ferranti M, Pamias Romero J, et al. Overview of oral potentially malignant disorders: from risk factors to specific therapies. Cancers 2021;13(15):3696 [DOI:10.3390/cancers13153696] [PMID] [PMCID]
7. Hwang JT, Gu YR, Shen M, Ralhan R, Walfish PG, Pritzker KP, et al. Individualized five-year risk assessment for oral premalignant lesion progression to cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(3):374-81 [DOI:10.1016/j.oooo.2016.11.004] [PMID]
8. Neville BW, Damm DD, Chi AC, Allen CM. Oral and maxillofacial pathology: Elsevier Health Sciences; 2016.
9. Ramos‐García P, González‐Moles MÁ, Warnakulasuriya S. Oral cancer development in lichen planus and related conditions-3.0 evidence level: a systematic review of systematic reviews. Oral Dis.2021;27(8):1919-1935.‏ [DOI:10.1111/odi.13812] [PMID]
10. Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L, et al. Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis.2019; 25(3):693-709.‏ [DOI:10.1111/odi.12885] [PMID]
11. Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS, et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Oral Oncol. 2017;68:92-102 [DOI:10.1016/j.oraloncology.2017.03.012] [PMID]
12. Parakh MK, Ulaganambi Sh, Ashifa N, Premkumar R, Jain Amit L. Oral potentially malignant disorders. Eur. J. Cancer Prev. 2020. 29(1): 65-72 [DOI:10.1097/CEJ.0000000000000510] [PMID]
13. Tsushima F, Sakurai J, Uesugi A, Oikawa Y, Ohsako T, Mochizuki Y, et al. Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients. BMC Oral Health2021;21(1):1-9.‏ [DOI:10.1186/s12903-021-01652-7] [PMID]
14. Lingam HT, Swetha P, Manyam R. Immunohistochemical evaluation of survivin in oral lichen planus and oral squamous cell carcinoma - a retrospective study. Med Pharm Rep. 2021;94(3):341-347. [DOI:10.15386/mpr-1746] [PMID] [PMCID]
15. Moosavi MS, Tavakol F. Literature review of cancer stem cells in oral lichen planus: a premalignant lesion. Stem Cell Investig 2021;8:25. [DOI:10.21037/sci-2020-049] [PMID] [PMCID]
16. Roy A. Molecular docking analysis of compounds from Andrographis paniculata with EGFR. Bioinformation. 2021;17(1):23-8 [DOI:10.6026/97320630017023] [PMID] [PMCID]
17. Cheng W-L, Feng P-H, Lee K-Y, Chen K-Y, Sun W-L, Van Hiep N, Luo C-S, Wu S-M. The role of EREG/EGFR pathway in tumor progression. Int J Mol Sci. 2021;22(23):12828 [DOI:10.3390/ijms222312828] [PMID] [PMCID]
18. Sabbah DA, Hajjo R, Sweidan K. Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors. Curr Top Med Chem. 2020;20(10):815-834 [DOI:10.2174/1568026620666200303123102] [PMID]
19. Baba Y, Maeda T, Suzuki A, Takada S, Fujii M, Kato Y. Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma. Int. J. Mol. Sci. 2017;18(2) [DOI:10.3390/ijms18020262] [PMID] [PMCID]
20. Nikitakis NG, Pentenero M, Georgaki M, Poh CF, Peterson E, Edwards P, et all. Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: current knowledge and future implications. Oral Surg Oral Med Oral Pathol Oral Radiol 2018;125(6)650-669 [DOI:10.1016/j.oooo.2018.03.012] [PMID]
21. Tseng YK, Chen CF, Shu CW, Lee CH, Chou YT, Li YJ, et al. Effect of EGFR on SQSTM1 Expression in Malignancy and Tumor Progression of Oral Squamous Cell Carcinoma. Int. J. Mol. Sci.2021;22(22): 12226. [DOI:10.3390/ijms222212226] [PMID] [PMCID]
22. Bhattacharyya S, Ray S, Saha D, Mustafi SM, Alam N, Sarkar A, et al. Chewing tobacco may act as a risk factor for dysplastic transformation of squamous cells in Oral leukoplakia- A cytochemistry based approach. Pathol. Res. Pract.2021; 218: 153287 [DOI:10.1016/j.prp.2020.153287] [PMID]
23. Shorghashti R, Sadri D, Farhadi S. Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst. J Res Dent Sci. 2020;17(2):127-136 [DOI:10.29252/jrds.17.2.127]
24. Ries J, Vairaktaris E, Agaimy A, Bechtold M, Gorecki P, Neukam FW, et al. The relevance of EGFR overexpression for the prediction of the malignant transformation of oral leukoplakia. Oncol. Rep. 2013;30(3):1149-56 [DOI:10.3892/or.2013.2545] [PMID]
25. Ribeiro M, Teixeira SR, Azevedo MN, Fraga AC, Jr., Gontijo AP, Vencio EF. Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma. Tumour Biol . 2017;39(4) [DOI:10.1177/1010428317695527] [PMID]
26. González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, Ayén Á, González-Ruiz L, Ruiz-Ávila I, Ramos-García P. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper. Med Oral Patol Oral Cir Bucal. 2021;26(4):e541-e548 [DOI:10.4317/medoral.24610] [PMID] [PMCID]
27. Zotti F, Nocini R, Capocasale G, Bertossi D, Fior A, Peretti M, Manfrin E, Albanese M. Oral Lichen Planus: risk factors of malignant transformation and follow up. Ten years retrospective study. J Clin Exp Dent 2021;13(7):630-6 [DOI:10.4317/jced.57688] [PMID] [PMCID]
28. Mutafchieva MZ, Draganova-Filipova MN, Zagorchev PI, Tomov GT.Oral Lichen Planus - Known and Unknown: a Review. Folia Med (Plovdiv) 2018;60(4):528-535 [DOI:10.2478/folmed-2018-0017] [PMID]
29. Kumagai K, Horikawa T, Gotoh A, Yamane S, Yamada H, Kobayashi H, et al. Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(6):748-54. [DOI:10.1016/j.tripleo.2010.06.022] [PMID]
30. Cortes-Ramirez DA, Rodriguez-Tojo MJ, Coca-Meneses JC, Marichalar-Mendia X, Aguirre-Urizar JM. Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease. Med Oral Patol Oral Cir Bucal. 2014;19(5):451-8. [DOI:10.4317/medoral.19452] [PMID] [PMCID]
31. Moorthy A, Venugopal DC, Shyamsundar V, Madhavan Y, Ravindran S, Kuppuloganathan M, et al. Identification of EGFR as a Biomarker in Saliva and Buccal Cells from Oral Submucous Fibrosis Patients-A Baseline Study. Diagnostics 2022;12(8),1935 [DOI:10.3390/diagnostics12081935] [PMID] [PMCID]
32. 2Adorno-Farias D, Badilla SM, Vidal GP, Fernandez-Ramires R. Epidermal Growth Factor Receptor (EGFR) is Overexpressed in Both Dysplasia and Neoplastic Oral Diseases. OMPJ 2022;13(2):73-78
33. Tan Y, Yan B, Xue L, Li Y, Luo X, Ji P. Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for the diagnosis of the oral squamous cell carcinoma. Lipids Health Dis. 2017;16(1):73 [DOI:10.1186/s12944-017-0465-y] [PMID] [PMCID]
34. Bakhtiari S, Mortazavi H, Mehdipour M, Jafarian N, Ranjbari N, Rahmani S. Frequency of Head and Neck Squamous Cell Carcinomas and Related Variables in Southern Iran (Ahvaz City): 10-Year Retrospective Study. Asian Pac. J. Cancer Prev. 2017;18(2):375-9
35. Yang Q, Guo B, Sun H, Zhang J, Liu S, Hexige S, et al. Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing. Oncol. Rep. 2017;37(4):2355-65 [DOI:10.3892/or.2017.5487] [PMID]
36. Lorini L, Bescós Atín C, Thavaraj S, Müller-Richter U, Alberola Ferranti M, Pamias Romero J, et al. Overview of oral potentially malignant disorders: from risk factors to specific therapies. Cancers 2021;13(15):3696 [DOI:10.3390/cancers13153696] [PMID] [PMCID]
37. Hwang JT, Gu YR, Shen M, Ralhan R, Walfish PG, Pritzker KP, et al. Individualized five-year risk assessment for oral premalignant lesion progression to cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(3):374-81 [DOI:10.1016/j.oooo.2016.11.004] [PMID]
38. Neville BW, Damm DD, Chi AC, Allen CM. Oral and maxillofacial pathology: Elsevier Health Sciences; 2016.
39. Ramos‐García P, González‐Moles MÁ, Warnakulasuriya S. Oral cancer development in lichen planus and related conditions-3.0 evidence level: a systematic review of systematic reviews. Oral Dis.2021;27(8):1919-1935.‏ [DOI:10.1111/odi.13812] [PMID]
40. Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L, et al. Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis.2019; 25(3):693-709.‏ [DOI:10.1111/odi.12885] [PMID]
41. Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS, et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Oral Oncol. 2017;68:92-102 [DOI:10.1016/j.oraloncology.2017.03.012] [PMID]
42. Parakh MK, Ulaganambi Sh, Ashifa N, Premkumar R, Jain Amit L. Oral potentially malignant disorders. Eur. J. Cancer Prev. 2020. 29(1): 65-72 [DOI:10.1097/CEJ.0000000000000510] [PMID]
43. Tsushima F, Sakurai J, Uesugi A, Oikawa Y, Ohsako T, Mochizuki Y, et al. Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients. BMC Oral Health2021;21(1):1-9.‏ [DOI:10.1186/s12903-021-01652-7] [PMID] [PMCID]
44. Lingam HT, Swetha P, Manyam R. Immunohistochemical evaluation of survivin in oral lichen planus and oral squamous cell carcinoma - a retrospective study. Med Pharm Rep. 2021;94(3):341-347. [DOI:10.15386/mpr-1746] [PMID] [PMCID]
45. Moosavi MS, Tavakol F. Literature review of cancer stem cells in oral lichen planus: a premalignant lesion. Stem Cell Investig 2021;8:25. [DOI:10.21037/sci-2020-049] [PMID] [PMCID]
46. Roy A. Molecular docking analysis of compounds from Andrographis paniculata with EGFR. Bioinformation. 2021;17(1):23-8 [DOI:10.6026/97320630017023] [PMID] [PMCID]
47. Cheng W-L, Feng P-H, Lee K-Y, Chen K-Y, Sun W-L, Van Hiep N, Luo C-S, Wu S-M. The role of EREG/EGFR pathway in tumor progression. Int J Mol Sci. 2021;22(23):12828 [DOI:10.3390/ijms222312828] [PMID] [PMCID]
48. Sabbah DA, Hajjo R, Sweidan K. Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors. Curr Top Med Chem. 2020;20(10):815-834 [DOI:10.2174/1568026620666200303123102] [PMID]
49. Baba Y, Maeda T, Suzuki A, Takada S, Fujii M, Kato Y. Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma. Int. J. Mol. Sci. 2017;18(2) [DOI:10.3390/ijms18020262] [PMID] [PMCID]
50. Nikitakis NG, Pentenero M, Georgaki M, Poh CF, Peterson E, Edwards P, et all. Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: current knowledge and future implications. Oral Surg Oral Med Oral Pathol Oral Radiol 2018;125(6)650-669 [DOI:10.1016/j.oooo.2018.03.012] [PMID]
51. Tseng YK, Chen CF, Shu CW, Lee CH, Chou YT, Li YJ, et al. Effect of EGFR on SQSTM1 Expression in Malignancy and Tumor Progression of Oral Squamous Cell Carcinoma. Int. J. Mol. Sci.2021;22(22): 12226. [DOI:10.3390/ijms222212226] [PMID] [PMCID]
52. Bhattacharyya S, Ray S, Saha D, Mustafi SM, Alam N, Sarkar A, et al. Chewing tobacco may act as a risk factor for dysplastic transformation of squamous cells in Oral leukoplakia- A cytochemistry based approach. Pathol. Res. Pract.2021; 218: 153287 [DOI:10.1016/j.prp.2020.153287] [PMID]
53. Shorghashti R, Sadri D, Farhadi S. Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst. J Res Dent Sci. 2020;17(2):127-136 [DOI:10.29252/jrds.17.2.127]
54. Ries J, Vairaktaris E, Agaimy A, Bechtold M, Gorecki P, Neukam FW, et al. The relevance of EGFR overexpression for the prediction of the malignant transformation of oral leukoplakia. Oncol. Rep. 2013;30(3):1149-56 [DOI:10.3892/or.2013.2545] [PMID]
55. Ribeiro M, Teixeira SR, Azevedo MN, Fraga AC, Jr., Gontijo AP, Vencio EF. Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma. Tumour Biol . 2017;39(4) [DOI:10.1177/1010428317695527] [PMID]
56. González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, Ayén Á, González-Ruiz L, Ruiz-Ávila I, Ramos-García P. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper. Med Oral Patol Oral Cir Bucal. 2021;26(4):e541-e548 [DOI:10.4317/medoral.24610] [PMID] [PMCID]
57. Zotti F, Nocini R, Capocasale G, Bertossi D, Fior A, Peretti M, Manfrin E, Albanese M. Oral Lichen Planus: risk factors of malignant transformation and follow up. Ten years retrospective study. J Clin Exp Dent 2021;13(7):630-6 [DOI:10.4317/jced.57688] [PMID] [PMCID]
58. Mutafchieva MZ, Draganova-Filipova MN, Zagorchev PI, Tomov GT.Oral Lichen Planus - Known and Unknown: a Review. Folia Med (Plovdiv) 2018;60(4):528-535 [DOI:10.2478/folmed-2018-0017] [PMID]
59. Kumagai K, Horikawa T, Gotoh A, Yamane S, Yamada H, Kobayashi H, et al. Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(6):748-54. [DOI:10.1016/j.tripleo.2010.06.022] [PMID]
60. Cortes-Ramirez DA, Rodriguez-Tojo MJ, Coca-Meneses JC, Marichalar-Mendia X, Aguirre-Urizar JM. Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease. Med Oral Patol Oral Cir Bucal. 2014;19(5):451-8. [DOI:10.4317/medoral.19452] [PMID] [PMCID]
61. Moorthy A, Venugopal DC, Shyamsundar V, Madhavan Y, Ravindran S, Kuppuloganathan M, et al. Identification of EGFR as a Biomarker in Saliva and Buccal Cells from Oral Submucous Fibrosis Patients-A Baseline Study. Diagnostics 2022;12(8),1935 [DOI:10.3390/diagnostics12081935] [PMID] [PMCID]
62. 2Adorno-Farias D, Badilla SM, Vidal GP, Fernandez-Ramires R. Epidermal Growth Factor Receptor (EGFR) is Overexpressed in Both Dysplasia and Neoplastic Oral Diseases. OMPJ 2022;13(2):73-78
63. Tan Y, Yan B, Xue L, Li Y, Luo X, Ji P. Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for the diagnosis of the oral squamous cell carcinoma. Lipids Health Dis. 2017;16(1):73 [DOI:10.1186/s12944-017-0465-y] [PMID]
64. Bakhtiari S, Mortazavi H, Mehdipour M, Jafarian N, Ranjbari N, Rahmani S. Frequency of Head and Neck Squamous Cell Carcinomas and Related Variables in Southern Iran (Ahvaz City): 10-Year Retrospective Study. Asian Pac. J. Cancer Prev. 2017;18(2):375-9
65. Yang Q, Guo B, Sun H, Zhang J, Liu S, Hexige S, et al. Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing. Oncol. Rep. 2017;37(4):2355-65 [DOI:10.3892/or.2017.5487] [PMID]
66. Lorini L, Bescós Atín C, Thavaraj S, Müller-Richter U, Alberola Ferranti M, Pamias Romero J, et al. Overview of oral potentially malignant disorders: from risk factors to specific therapies. Cancers 2021;13(15):3696 [DOI:10.3390/cancers13153696] [PMID] [PMCID]
67. Hwang JT, Gu YR, Shen M, Ralhan R, Walfish PG, Pritzker KP, et al. Individualized five-year risk assessment for oral premalignant lesion progression to cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(3):374-81 [DOI:10.1016/j.oooo.2016.11.004] [PMID]
68. Neville BW, Damm DD, Chi AC, Allen CM. Oral and maxillofacial pathology: Elsevier Health Sciences; 2016.
69. Ramos‐García P, González‐Moles MÁ, Warnakulasuriya S. Oral cancer development in lichen planus and related conditions-3.0 evidence level: a systematic review of systematic reviews. Oral Dis.2021;27(8):1919-1935.‏ [DOI:10.1111/odi.13812] [PMID]
70. Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L, et al. Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis.2019; 25(3):693-709.‏ [DOI:10.1111/odi.12885] [PMID]
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72. Parakh MK, Ulaganambi Sh, Ashifa N, Premkumar R, Jain Amit L. Oral potentially malignant disorders. Eur. J. Cancer Prev. 2020. 29(1): 65-72 [DOI:10.1097/CEJ.0000000000000510] [PMID]
73. Tsushima F, Sakurai J, Uesugi A, Oikawa Y, Ohsako T, Mochizuki Y, et al. Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients. BMC Oral Health2021;21(1):1-9.‏ [DOI:10.1186/s12903-021-01652-7] [PMID] [PMCID]
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75. Moosavi MS, Tavakol F. Literature review of cancer stem cells in oral lichen planus: a premalignant lesion. Stem Cell Investig 2021;8:25. [DOI:10.21037/sci-2020-049] [PMID] [PMCID]
76. Roy A. Molecular docking analysis of compounds from Andrographis paniculata with EGFR. Bioinformation. 2021;17(1):23-8 [DOI:10.6026/97320630017023] [PMID] [PMCID]
77. Cheng W-L, Feng P-H, Lee K-Y, Chen K-Y, Sun W-L, Van Hiep N, Luo C-S, Wu S-M. The role of EREG/EGFR pathway in tumor progression. Int J Mol Sci. 2021;22(23):12828 [DOI:10.3390/ijms222312828] [PMID] [PMCID]
78. Sabbah DA, Hajjo R, Sweidan K. Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors. Curr Top Med Chem. 2020;20(10):815-834 [DOI:10.2174/1568026620666200303123102] [PMID]
79. Baba Y, Maeda T, Suzuki A, Takada S, Fujii M, Kato Y. Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma. Int. J. Mol. Sci. 2017;18(2) [DOI:10.3390/ijms18020262] [PMID] [PMCID]
80. Nikitakis NG, Pentenero M, Georgaki M, Poh CF, Peterson E, Edwards P, et all. Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: current knowledge and future implications. Oral Surg Oral Med Oral Pathol Oral Radiol 2018;125(6)650-669 [DOI:10.1016/j.oooo.2018.03.012] [PMID]
81. Tseng YK, Chen CF, Shu CW, Lee CH, Chou YT, Li YJ, et al. Effect of EGFR on SQSTM1 Expression in Malignancy and Tumor Progression of Oral Squamous Cell Carcinoma. Int. J. Mol. Sci.2021;22(22): 12226. [DOI:10.3390/ijms222212226] [PMID] [PMCID]
82. Bhattacharyya S, Ray S, Saha D, Mustafi SM, Alam N, Sarkar A, et al. Chewing tobacco may act as a risk factor for dysplastic transformation of squamous cells in Oral leukoplakia- A cytochemistry based approach. Pathol. Res. Pract.2021; 218: 153287 [DOI:10.1016/j.prp.2020.153287] [PMID]
83. Shorghashti R, Sadri D, Farhadi S. Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst. J Res Dent Sci. 2020;17(2):127-136 [DOI:10.29252/jrds.17.2.127]
84. Ries J, Vairaktaris E, Agaimy A, Bechtold M, Gorecki P, Neukam FW, et al. The relevance of EGFR overexpression for the prediction of the malignant transformation of oral leukoplakia. Oncol. Rep. 2013;30(3):1149-56 [DOI:10.3892/or.2013.2545] [PMID]
85. Ribeiro M, Teixeira SR, Azevedo MN, Fraga AC, Jr., Gontijo AP, Vencio EF. Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma. Tumour Biol . 2017;39(4) [DOI:10.1177/1010428317695527] [PMID]
86. González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, Ayén Á, González-Ruiz L, Ruiz-Ávila I, Ramos-García P. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper. Med Oral Patol Oral Cir Bucal. 2021;26(4):e541-e548 [DOI:10.4317/medoral.24610] [PMID] [PMCID]
87. Zotti F, Nocini R, Capocasale G, Bertossi D, Fior A, Peretti M, Manfrin E, Albanese M. Oral Lichen Planus: risk factors of malignant transformation and follow up. Ten years retrospective study. J Clin Exp Dent 2021;13(7):630-6 [DOI:10.4317/jced.57688] [PMID] [PMCID]
88. Mutafchieva MZ, Draganova-Filipova MN, Zagorchev PI, Tomov GT.Oral Lichen Planus - Known and Unknown: a Review. Folia Med (Plovdiv) 2018;60(4):528-535 [DOI:10.2478/folmed-2018-0017] [PMID]
89. Kumagai K, Horikawa T, Gotoh A, Yamane S, Yamada H, Kobayashi H, et al. Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(6):748-54. [DOI:10.1016/j.tripleo.2010.06.022] [PMID]
90. Cortes-Ramirez DA, Rodriguez-Tojo MJ, Coca-Meneses JC, Marichalar-Mendia X, Aguirre-Urizar JM. Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease. Med Oral Patol Oral Cir Bucal. 2014;19(5):451-8. [DOI:10.4317/medoral.19452] [PMID] [PMCID]
91. Moorthy A, Venugopal DC, Shyamsundar V, Madhavan Y, Ravindran S, Kuppuloganathan M, et al. Identification of EGFR as a Biomarker in Saliva and Buccal Cells from Oral Submucous Fibrosis Patients-A Baseline Study. Diagnostics 2022;12(8),1935 [DOI:10.3390/diagnostics12081935] [PMID] [PMCID]
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93. Tan Y, Yan B, Xue L, Li Y, Luo X, Ji P. Surface-enhanced Raman spectroscopy of blood serum based on gold nanoparticles for the diagnosis of the oral squamous cell carcinoma. Lipids Health Dis. 2017;16(1):73 [DOI:10.1186/s12944-017-0465-y] [PMID] [PMCID]
94. Bakhtiari S, Mortazavi H, Mehdipour M, Jafarian N, Ranjbari N, Rahmani S. Frequency of Head and Neck Squamous Cell Carcinomas and Related Variables in Southern Iran (Ahvaz City): 10-Year Retrospective Study. Asian Pac. J. Cancer Prev. 2017;18(2):375-9
95. Yang Q, Guo B, Sun H, Zhang J, Liu S, Hexige S, et al. Identification of the key genes implicated in the transformation of OLP to OSCC using RNA-sequencing. Oncol. Rep. 2017;37(4):2355-65 [DOI:10.3892/or.2017.5487] [PMID]
96. Lorini L, Bescós Atín C, Thavaraj S, Müller-Richter U, Alberola Ferranti M, Pamias Romero J, et al. Overview of oral potentially malignant disorders: from risk factors to specific therapies. Cancers 2021;13(15):3696 [DOI:10.3390/cancers13153696] [PMID] [PMCID]
97. Hwang JT, Gu YR, Shen M, Ralhan R, Walfish PG, Pritzker KP, et al. Individualized five-year risk assessment for oral premalignant lesion progression to cancer. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(3):374-81 [DOI:10.1016/j.oooo.2016.11.004] [PMID]
98. Neville BW, Damm DD, Chi AC, Allen CM. Oral and maxillofacial pathology: Elsevier Health Sciences; 2016.
99. Ramos‐García P, González‐Moles MÁ, Warnakulasuriya S. Oral cancer development in lichen planus and related conditions-3.0 evidence level: a systematic review of systematic reviews. Oral Dis.2021;27(8):1919-1935.‏ [DOI:10.1111/odi.13812] [PMID]
100. Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, Lo Muzio L, et al. Rate of malignant transformation of oral lichen planus: A systematic review. Oral Dis.2019; 25(3):693-709.‏ [DOI:10.1111/odi.12885]
101. Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS, et al. Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Oral Oncol. 2017;68:92-102 [DOI:10.1016/j.oraloncology.2017.03.012] [PMID]
102. Parakh MK, Ulaganambi Sh, Ashifa N, Premkumar R, Jain Amit L. Oral potentially malignant disorders. Eur. J. Cancer Prev. 2020. 29(1): 65-72 [DOI:10.1097/CEJ.0000000000000510] [PMID]
103. Tsushima F, Sakurai J, Uesugi A, Oikawa Y, Ohsako T, Mochizuki Y, et al. Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients. BMC Oral Health2021;21(1):1-9.‏ [DOI:10.1186/s12903-021-01652-7] [PMID] [PMCID]
104. Lingam HT, Swetha P, Manyam R. Immunohistochemical evaluation of survivin in oral lichen planus and oral squamous cell carcinoma - a retrospective study. Med Pharm Rep. 2021;94(3):341-347. [DOI:10.15386/mpr-1746] [PMID] [PMCID]
105. Moosavi MS, Tavakol F. Literature review of cancer stem cells in oral lichen planus: a premalignant lesion. Stem Cell Investig 2021;8:25. [DOI:10.21037/sci-2020-049] [PMID] [PMCID]
106. Roy A. Molecular docking analysis of compounds from Andrographis paniculata with EGFR. Bioinformation. 2021;17(1):23-8 [DOI:10.6026/97320630017023] [PMID] [PMCID]
107. Cheng W-L, Feng P-H, Lee K-Y, Chen K-Y, Sun W-L, Van Hiep N, Luo C-S, Wu S-M. The role of EREG/EGFR pathway in tumor progression. Int J Mol Sci. 2021;22(23):12828 [DOI:10.3390/ijms222312828] [PMID] [PMCID]
108. Sabbah DA, Hajjo R, Sweidan K. Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors. Curr Top Med Chem. 2020;20(10):815-834 [DOI:10.2174/1568026620666200303123102] [PMID]
109. Baba Y, Maeda T, Suzuki A, Takada S, Fujii M, Kato Y. Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma. Int. J. Mol. Sci. 2017;18(2) [DOI:10.3390/ijms18020262] [PMID] [PMCID]
110. Nikitakis NG, Pentenero M, Georgaki M, Poh CF, Peterson E, Edwards P, et all. Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: current knowledge and future implications. Oral Surg Oral Med Oral Pathol Oral Radiol 2018;125(6)650-669 [DOI:10.1016/j.oooo.2018.03.012]
111. Tseng YK, Chen CF, Shu CW, Lee CH, Chou YT, Li YJ, et al. Effect of EGFR on SQSTM1 Expression in Malignancy and Tumor Progression of Oral Squamous Cell Carcinoma. Int. J. Mol. Sci.2021;22(22): 12226. [DOI:10.3390/ijms222212226] [PMID] [PMCID]
112. Bhattacharyya S, Ray S, Saha D, Mustafi SM, Alam N, Sarkar A, et al. Chewing tobacco may act as a risk factor for dysplastic transformation of squamous cells in Oral leukoplakia- A cytochemistry based approach. Pathol. Res. Pract.2021; 218: 153287 [DOI:10.1016/j.prp.2020.153287] [PMID]
113. Shorghashti R, Sadri D, Farhadi S. Expression of Epidermal Growth Factor Receptor by Odontogenic Cysts: A comparative Study of Dentigerous Cyst and Odontogenic Keratocyst. J Res Dent Sci. 2020;17(2):127-136 [DOI:10.29252/jrds.17.2.127]
114. Ries J, Vairaktaris E, Agaimy A, Bechtold M, Gorecki P, Neukam FW, et al. The relevance of EGFR overexpression for the prediction of the malignant transformation of oral leukoplakia. Oncol. Rep. 2013;30(3):1149-56 [DOI:10.3892/or.2013.2545] [PMID]
115. Ribeiro M, Teixeira SR, Azevedo MN, Fraga AC, Jr., Gontijo AP, Vencio EF. Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma. Tumour Biol . 2017;39(4) [DOI:10.1177/1010428317695527] [PMID]
116. González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, Ayén Á, González-Ruiz L, Ruiz-Ávila I, Ramos-García P. Dysplasia in oral lichen planus: relevance, controversies and challenges. A position paper. Med Oral Patol Oral Cir Bucal. 2021;26(4):e541-e548 [DOI:10.4317/medoral.24610] [PMID] [PMCID]
117. Zotti F, Nocini R, Capocasale G, Bertossi D, Fior A, Peretti M, Manfrin E, Albanese M. Oral Lichen Planus: risk factors of malignant transformation and follow up. Ten years retrospective study. J Clin Exp Dent 2021;13(7):630-6 [DOI:10.4317/jced.57688] [PMID] [PMCID]
118. Mutafchieva MZ, Draganova-Filipova MN, Zagorchev PI, Tomov GT.Oral Lichen Planus - Known and Unknown: a Review. Folia Med (Plovdiv) 2018;60(4):528-535 [DOI:10.2478/folmed-2018-0017] [PMID]
119. Kumagai K, Horikawa T, Gotoh A, Yamane S, Yamada H, Kobayashi H, et al. Up-regulation of EGF receptor and its ligands, AREG, EREG, and HB-EGF in oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110(6):748-54. [DOI:10.1016/j.tripleo.2010.06.022] [PMID]
120. Cortes-Ramirez DA, Rodriguez-Tojo MJ, Coca-Meneses JC, Marichalar-Mendia X, Aguirre-Urizar JM. Epidermal growth factor receptor expression in different subtypes of oral lichenoid disease. Med Oral Patol Oral Cir Bucal. 2014;19(5):451-8. [DOI:10.4317/medoral.19452] [PMID] [PMCID]
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keshani F, fallah F, mosayebi samani F, esfandpour A, kargahi N. Comparison of EGFR (Epithelial Growth Factor Receptor) expression as a protein marker in Oral Erosive & Reticular Lichen Planus and Oral Epithelial Dysplasia. J Res Dent Sci 2023; 20 (2) :25-34
URL: http://jrds.ir/article-1-1338-fa.html

کشانی فروز، فلاح فاطمه، مسیبی سامانی فاطمه، اسفندپور عاطفه، کارگهی ندا. مقایسه ی بروز گیرنده فاکتور رشد اپیتلیالی EGFR در ضایعات لیکن پلان دهانی اروزیو ، رتیکولر و دیس پلازی اپیتلیالی. مجله تحقیق در علوم دندانپزشکی. 1402; 20 (2) :25-34

URL: http://jrds.ir/article-1-1338-fa.html



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مجله تحقیق در علوم دندانپزشکی Res Dent Sci
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