Abstract:

  Background and Aim: The aim of this study was to comparison Salivary Cortisol, sIgA & Anxiety in oral Lichen Planus (OLP) patients and control group without OLP.

  Materials and Methods : 46 patients with OLP and46 without OLP were admitted to this case – control study. Salivary cortisol &sIgA were detected by ELISA and anxiety was investigated by the Spielberger state-trait tools. The level of stress and anxiety were compared with other variables by t- test and ANOVA and Logistic regression were carried out. ROC curve was utilized as an anticipator for variables and sensitivity and specificity for salivary cortisol and sIgA were established

  Results : : 36women and 10 men with mean age 47.1 years were recruited in this study. The mean salivary cortisol level 3.42 nmol/L (95% CI 2.69-4.14) and mean sIgA level 191.59 nmol/L(95% CI 155.19-227.97)had significant difference (p < 0.0001) . No significant differences were shown by anxiety states tool (42.95 vs. 47.67). (P<0.4) Salivary cortisol’s cut-off point (1.6nmol/L) and sIgA (296.15nmol/ L) were determined respectively in oral lichen planus patients. Area under Curve were estimated for salivary cortisol (0.851) and sIgA(0.797).By rising per unit in salivary cortisol the risk of OLP were increase (OR: 5.9, 95% CI 2.36-4.97) otherwise by decreasing per unit of sIgA the risk of OLP may rise (OR: 0.9, 95% CI 0.989-0.995).

  Conclusion: Findings revealed that levels of salivary cortisol and sIgA had significant correlation with OLP hence it could be a possible indicator for the pathogenesis and/or progression of OLP