journal of research in dental sciences
مجله تحقیق در علوم دندانپزشکی
J Res Dent Sci
Medical Sciences
http://jrds.ir
1
admin
2008-4676
2228-7353
8
10.66224/jrds
14
13
fa
jalali
1402
9
1
gregorian
2023
12
1
20
4
online
1
fulltext
fa
بررسی میزان ویتامین D سرم، نسبت نوتروفیل به لنفوسیت و میانگین حجم پلاکت در افراد مبتلا به آفت راجعه دهان
Evaluation of serum vitamin D level, neutrophil to lymphocyte ratio and mean platelet volume in patients with recurrent aphthous stomatitis
بیماری دهان
Oral Medicine
مطالعه اصیل
original article
<br>
<span style="font-size:12pt"><span style="line-height:115%"><span style="text-autospace:none"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="color:black">سابقه و هدف</span></span></b><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="color:black">: </span></span><span lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">استوماتیت آفتی راجعه (</span></span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:115%"><span style="color:black">RAS</span></span></span><span lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">) اختلالی است که با زخم های عود کننده محدود به مخاط دهان در بیمارانی که هیچ نشانه دیگری از بیماری سیستمیک ندارند مشخص می گردد. فاکتور های اصلی که در حال حاضر با </span></span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:115%"><span style="color:black">RAS</span></span></span><span lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> در ارتباط هستند شامل عوامل ژنتیکی، نقایص هماتولوژیک، مشکلات ایمونولوژیک و عوامل موضعی مثل تروما می باشد. هدف از این مطالعه بررسی میزان ویتامین </span></span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:115%"><span style="color:black">D</span></span></span><span lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> سرم و نسبت نوتروفیل به لنفوسیت و میانگین حجم پلاکت در بیماران مبتلا به </span></span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:115%"><span style="color:black">RAS</span></span></span><span lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> است.</span></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:115%"><span style="text-autospace:none"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" lang="FA" nazanin="" style="font-family:"><span style="color:black">مواد و روش ها:</span></span></b> <span lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black">در این مطالعه مورد-شاهدی 30 بیمار مبتلا به </span></span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:115%"><span style="color:black">RAS</span></span></span><span lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> و 30 فرد سالم به عنوان کنترل با هم مقایسه شدند و از نمونه های سرم جهت ارزیابی ویتامین </span></span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:115%"><span style="color:black">D</span></span></span><span lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> سرم، نسبت نوتروفیل به لنفوسیت و میانگین حجم پلاکت استفاده شدند. یافته ها با آزمون </span></span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:115%"><span style="color:black">Mann-Whitney</span></span></span><span lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> و </span></span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="line-height:115%"><span style="color:black">Sample -t-test</span></span></span><span lang="FA" style="font-size:11.0pt"><span style="line-height:115%"><span b="" nazanin="" style="font-family:"><span style="color:black"> مورد بررسی قرار گرفت. </span></span></span></span></span></span></span></span></span></span><br>
<span style="direction:rtl"><span style="unicode-bidi:embed"><b><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="color:black">یافته ها</span></span></b><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="color:black">: </span></span> <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">میزان ویتامین </span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">D</span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> سرم در بیماران مبتلا </span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black"> ng/ml <a name="_Hlk73027524"> </a>RAS </span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">12/09±21/44 و در افراد سالم</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">ng/ml</span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> 18/65± 24/87بود ، همچنین نسبت نوتروفیل به لنفوسیت در بیماران مبتلا به </span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">RAS</span></span> <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">1.23 ± 1.89 و در افراد سالم 1/79 ± 2/03 بود </span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black"></span></span></span></span><br>
<span style="direction:rtl"><span style="unicode-bidi:embed"><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">و میانگین حجم پلاکت در بیماران مبتلا به </span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">RAS</span></span> <span dir="LTR" style="font-size:11.0pt"><span style="color:black">fl,</span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> 93/0 </span></span></span><span lang="FA" style="font-size:11.0pt"><span style="color:black">±</span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"></span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black"></span></span><span style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"></span></span></span> <span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">36/10 و در افراد سالم </span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">fl</span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> 12/1 ± 65/10 بود. هر سه نشانگر بین دو گروه تفاوت معناداری نداشتند. به ترتیب (0/4= </span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">P</span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">) و (0/8=</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">P</span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">) و (0/27=</span></span></span><span dir="LTR" style="font-size:11.0pt"><span style="color:black">P</span></span><span lang="FA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">)</span></span></span></span></span><br>
<span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="color:black">ﻧﺘﻴﺠﻪ ﮔﻴﺮی</span></span></b><span b="" lang="AR-SA" nazanin="" style="font-family:"><span style="color:black">:</span></span> <span lang="AR-SA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">به نظر می رسد که میزان ویتامین</span></span></span><span dir="LTR" style="font-size:11.0pt"><span bold="" new="" roman="" style="font-family:" times=""><span style="color:black"> D </span></span></span><span lang="AR-SA" style="font-size:11.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">سرم و نسبت نوتروفیل به لنفوسیت و میانگین حجم پلاکت در بین افراد مبتلا به آفت دهانی و افراد سالم تفاوت معنی داری ندارد.</span></span></span></span></span></span></span><br>
<br>
<span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b>Background and Aim:</b> <span style="font-size:10.0pt">Recurrent Aphthous Stomatitis (RAS) is a disorder characterized by recurrent ulcers limited to oral mucosa in patients who have no other symptoms of systemic disease. The main factors currently associated with RAS include genetic factors, hematological defects, immunological problems and local conditions such as trauma and smoking. The aim of this study was to evaluated serum vitamin D levels, neutrophil to lymphocyte ratio and mean platelet volume in patients with RAS.</span></span></span><br>
<span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b>Materials and methods:</b> <span style="font-size:10.0pt">In this case control study, 30 patients with RAS and 30 healthy individuals were compared as controls, serum samples were evaluated for vitamin D, neutrophil to lymphocyte ratio and mean platelet volume. Findings were analyzed by Mann- Whitney and sample-t-test. </span></span></span><br>
<span style="font-size:12pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b>Results:</b><span dir="LTR" style="font-size:10.0pt"> Serum vitamin D levels in patients with RAS were 21.44±12.09 ng/ml and in healthy individuals were 24.87 ±18.65 ng/ml . Also neutrophil to lymphocyte ratio in patients with RAS were 1.89± 1.23 and in healthy individuals were 2.03± 1.79. Mean platelet volume in patients with RAS were 10.36± 0.93 fl and in healthy individuals were 10.65 ±1.12 fl . There was no significant difference between the two groups. All three markers were not significantly different between the two groups. respectively (P=0.4), (P=0.8) and (P=0.27)</span></span></span></span></span><br>
<span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><b>Conclusion:</b><span lang="EN" style="font-size:10.0pt">It seems that serum vitamin D levels and neutrophil to lymphocyte ratio and mean platelet volume not statistically significant in patients with RAS and healthy individuals. </span></span></span><br>
<span style="font-size:12pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:10.0pt"></span></span></span><br>
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آفت دهانی , ویتامینD , میانگین حجم پلاکت, نوتروفیل ها
Aphthous Stomatitis , Vitamin D ,Mean Platelet Volume,Neutrophils
174
180
http://jrds.ir/browse.php?a_code=A-10-1498-2&slc_lang=fa&sid=1
Marieh
Honarmand
ماریه
هنرمند
honarmand56@yahoo.com
100319475328460020302
100319475328460020302
Yes
University of Medical Sciences
عضو مرکز تحقیقات بیماریهای دهان و دندان، گروه بیماریهای دهان، دانشکده دندانپزشکی، دانشگاه علوم پزشکی زاهدان، زاهدان، ایران
Sahar
Khashi
سحر
خاشی
100319475328460020303
0009-0002-3295-9665
No
University of Medical Sciences
دندانپزشک عمومی