Abstract:

  Background and Aim : Periodontitis is a chronic multi factorial infectious disease ,characterized by the irreversible destruction of collagen fibers and other matrix constituents of the gingival tissues, periodontal ligament and resorption of alveolar bone around the teeth with the formation of periodontal pocket. During the course of injury, destructions and death of stromal, epithelial or inflammatory cells, different enzymes are released, which can be used as indicators in diagnostic and treatment. The aim of this study was to compare the alkaline phosphase level of saline in patients with Periodontitis and normal ones.

  Materials and Methods: In this experimental study, unstimulated saliva of 20 patients with mild periodontitis, 20 patients with moderate to severe periodontitis, and 20 subjects with healthy periodontium were collected. The mean levels of alkaline transferase salivary enzymes were measured by kinetic system. Finally data were analyzed by ANOVA and TUKEY tests.

  Results :

  Mean level of Alkaline phosphatase salivary enzyme in healthy gingival group was 9.25 ± 4.3,in mild periodontitis group was 21.3 ±7.6 and in moderate to severe periodontitis group was 33.75 ±11.9 and there was significant differences between three groups (P<0.05).

  Conclusion : The results revealed that salivary alkaline transferaze level is a good indicator to determine the degree of periodontal tissue destruction.

  Key words : Alkaline transferase, saliva, periodontal disease