journal of research in dental sciences

fa مقایسه اثر داکسی سایکلین با شیرین بیان بر پریودنتیت مزمن – مطالعه کارآزمایی بالینی Comparison of the Effect of Doxycycline and Licorice on Chronic Periodontitis – A Clinical Trial Study جراحی- oral surgery مطالعه اصیل original article   <p align="left" dir="rtl" style="margin: 0cm 0cm 0pt text-align: justify line-height: 115% text-indent: 14.2pt unicode-bidi: embed direction: rtl -ms-text-justify: kashida text-kashida: 0% mso-pagination: none">    <h5 align="left" dir="rtl" style="margin: 0cm 0cm 0pt text-align: justify unicode-bidi: embed direction: rtl"><span align="left" b="" dir="rtl" face="Times New Roman" font="" lang="AR-SA" mso-ascii-font-family:="" mso-bidi-font-family:="" mso-hansi-font-family:="" new="" p="" roman="" size="3" span="" style="font-family: " times="">سابقه و هدف: (HMT روشی نوین است که به عنوان درمان جانبی بیماری های پریودنتال به کار می رود. از طرفی قرص شیرین بیان حاوی عصاره ای است که می تواند اثرات ضد التهابی داشته باشد و از طرفی دیگر به دلیل تمایل بیشتر بیماران به مصرف داروی گیاهی، لازم دانستیم تا به مقایسه اثر قرص شیرین بیان با داکسی سایکلین بر روی پریودنتیت مزمن بپردازیم.</h5>    (PD، از دست رفتن چسبندگی<span 11pt="" adobe="" b="" dir="ltr" fa="" face="Times New Roman" font="" font-size:="" garamond="" lang="FA" mso-ascii-font-family:="" mso-bidi-language:="" mso-hansi-font-family:="" pro="" span="" style="font-family: ">)(BOP ثبت شد. <span .="" 20="" 3="" 490="" :="" adobe="" b="" dir="ltr" fa="" face="Times New Roman" font="" garamond="" lang="FA" mso-ascii-font-family:="" mso-bidi-language:="" mso-hansi-font-family:="" pro="" span="" style="font-family: ">زوجی، آنالیز ANOVA<span adobe="" align="left" b="" dir="rtl" fa="" face="Times New Roman" font="" garamond="" lang="AR-SA" mso-ascii-font-family:="" mso-bidi-language:="" mso-hansi-font-family:="" new="" p="" pro="" roman="" size="3" span="" style="font-family: " times="">یافته‌ها: میانگین PD، CAL وBOP پس از درمان در هر سه گروه به طور معنی داری کاهش یافته بود.(05/0>P) اختلاف میانگینPD، CAL وBOP بین دو گروه داکسی سایکلین و شیرین بیان معنادار نبود. به ترتیب (54/0P =)، (74/0P =) و (64/0P =)   : شیرین بیان همانند داکسی سایکلین شاخص های کلینیکی پریودنتال را در پریودنتیت مزمن کاهش میدهد.       <span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times="">Abstract   Background and Aim<span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times="">: Host modulatory therapy (HMT) is a new method that has been used as adjunctive therapy for periodontal diseases. Licorice<span 12pt="" b="" calibri="" dir="rtl" fa="" font-size:="" major-bidi="" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times=""> <span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times="">tablet contains an extract with anti-inflammatory<span 12pt="" b="" calibri="" dir="rtl" fa="" font-size:="" major-bidi="" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times=""> <span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times="">effects. Considering that most patients prefer to take herbal medications. we found it necessary to compare the effects of licorice tablet and doxycycline on chronic periodontitis<span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times="">.   <span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times="">    <span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times="">Materials and Methods: In this interventional clinical trial study, 45 patients with<span 12pt="" b="" calibri="" dir="rtl" fa="" font-size:="" major-bidi="" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times=""> <span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times="">mild to moderate chronic periodontitis were selected. Plaque Index (PI), Pocket Depth (PD), Clinical Attachment Loss (CAL) and Bleeding on Probing (BOP) were recorded for all periodontal patients. Then scaling and root<span 12pt="" b="" calibri="" dir="rtl" fa="" font-size:="" major-bidi="" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times=""> <span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times="">planning was done and patients were divided into three groups.   <span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times="">In the first group, a 20mg doxycycline capsule was given to each patient daily, the second group was given a 490mg licorice tablet per day and the third group was given a placebo capsule per day. After 6 weeks, all the above-mentioned parameters were recorded again for all patients. Chi-square, paired sample T and one-way ANOVA tests were used for data analysis.   <span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black font-family: " times="">    <span 12pt="" b="" calibri="" fa="" font-size:="" major-bidi="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-hansi-theme-font:="" mso-themecolor:="" new="" style="color: black line-height: 150% font-family: " times="">Results: The mean of PD, CAL and BOP after treatment reduced significantly within the three groups (P <0.05). The mean difference of PD, CAL and BOP between the two groups of doxycycline and licorice was not significant (P =0.54, 0.74 and 0.64, respectively).   Conclusion: licorice decreases clinical periodontal indices of similar to doxycycline in chronic periodontitis.   پریودنتیت مزمن, داکسی سایکلین, شیرین بیان Chronic periodontitis, Doxycycline, Licorice, Clinical Trial 123 129 http://jrds.ir/browse.php?a_code=A-10-875-1&slc_lang=fa&sid=1 T Mahmudpourmoteshakker طهمورث محمود پور متشکر t.mahmudpour@yahoo.com 10031947532846009626 10031947532846009626 Yes Assistant Professor of Microbiology, Dept .of Basic Medical Sciences, Isfahan Azad University (Khorasgan Branch), Isfahan, Iran Assistant Professor of Microbiology, Dept .of Basic Medical Sciences, Isfahan Azad University (Khorasgan Branch), Isfahan, Iran E Rafiee احسان رفیعی 10031947532846009627 10031947532846009627 No Assistant Professor, Periodontics Dept, School of Dentistry, Islamic Azad University, Isfahan (Khorasgan), Iran Assistant Professor, Periodontics Dept, School of Dentistry, Islamic Azad University, Isfahan (Khorasgan), Iran SHZ Farhad شیرین زهرا فرهاد 10031947532846009628 10031947532846009628 No Assistant Professor, Periodontics Dept, School of Dentistry, Islamic Azad University, Isfahan (Khorasgan), Iran Assistant Professor, Periodontics Dept, School of Dentistry, Islamic Azad University, Isfahan (Khorasgan), Iran A Aminzadeh آتوسا امین زاده 10031947532846009629 10031947532846009629 No Assistant Professor Oral and Maxillofacial Pathology Dept, School of Dentistry, Islamic Azad University, Isfahan (Khorasgan), Iran Assistant Professor Oral and Maxillofacial Pathology Dept, School of Dentistry, Islamic Azad University, Isfahan (Khorasgan), Iran