Background and Aim: Materials and methods: Results: Conclusion: <span style="line-height: 150% font-size: 13pt mso-fareast-font-family: " times="" new="" roman"="" mso-bidi-font-family:="" "times="" mso-bidi-language:="" fa"="">Results showed that the effect of disinfectant solutions on surface roughness of Meliodent acrylic is higher than Acropars and the least destructive effect was for Corega tabs. Usage of chlorinated solutions for disinfecting Meliodent acrylic and acidic solutions for Acropars is not recommended.