fa بررسی میزان IFN-δ و IL-4 در بزاق مبتلایان به لیکن پلان دهانی جراحی- oral surgery مطالعه اصیل original article <h5 style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify LINE-HEIGHT: 115% TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><font size="2"><b><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman Bold' mso-hansi-font-family: 'Times New Roman Bold'">خلاصه: </span></b><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman Bold' mso-hansi-font-family: 'Times New Roman Bold'"><p></p></span></font></h5><h5 style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><span><font size="2">سابقه و هدف: گزارشات متفاوتی در رابطه با تغییرات سطح بزاقی اینترکولین‌ 4 و اینترفرون گاما در بیماران مبتلا به لیکن پلان وجود دارد اما همواره پاتوژنر این بیماری مورد سوال است. هدف از این مطالعه ارزیابی سطح بزاقی این نشانگر، در بیماران مبتلا به لیکن پلان دهانی بود.</font></span></h5><h5 style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><span><p><h5 style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><font size="2"><span>مواد و روش ها: در این مطالعه مورد- شاهدی بزاق 84 نمونه شامل 30 بیمار مبتلا به لیکن پلان دهانی و 54 فرد سالم که ضایعه مخاطی نداشتند بررسی شد. نمونه‌های بزاقی جهت ارزیابی میزان اینترکولین 4 و اینترفرون گاما به روش الایزا بررسی شدند و یافته‌ها با آزمون </span><span style="mso-bidi-language: FA mso-ansi-language: EN-US" dir="ltr"><font face="Times New Roman">Mann-U-Whitney</font></span><span><span dir="rtl"></span> </span><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ansi-language: EN-US mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri">و آزمون‌های همبستگی پیرسون و اسپیرمن مورد بررسی قرار گرفت.<p></p></span></font></h5><h5 style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><font size="2"><span>یافته‌ها: میزان </span><span style="mso-bidi-language: FA mso-ansi-language: EN-US" dir="ltr"><font face="Times New Roman">IFN-δ</font></span><span><span dir="rtl"></span> </span><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman Bold' mso-hansi-font-family: 'Times New Roman Bold'">در مبتلایان به لیکن پلان دهانی و افراد سالم به ترتیب، (3/4</span><span lang="FA" style="mso-bidi-language: FA"><font face="Times New Roman">±</font></span><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman Bold' mso-hansi-font-family: 'Times New Roman Bold'">48/4) و (7/2</span><span lang="FA" style="mso-bidi-language: FA"><font face="Times New Roman">±</font></span><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman Bold' mso-hansi-font-family: 'Times New Roman Bold'">54/3) و میزان </span><span style="mso-bidi-language: FA mso-ansi-language: EN-US" dir="ltr"><font face="Times New Roman">IL-4</font></span><span><span dir="rtl"></span> </span><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman Bold' mso-hansi-font-family: 'Times New Roman Bold'">به ترتیب<font face="B Nazanin"><span style="mso-spacerun: yes">  </span>(07/11</font></span><span lang="FA" style="mso-bidi-language: FA"><font face="Times New Roman">±</font></span><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman Bold' mso-hansi-font-family: 'Times New Roman Bold'">28/3) و (3/6</span><span lang="FA" style="mso-bidi-language: FA"><font face="Times New Roman">±</font></span><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman Bold' mso-hansi-font-family: 'Times New Roman Bold'">86/2) بود. (8/0= </span><span style="FONT-FAMILY: 'Calibri','sans-serif' mso-bidi-font-family: 'B Nazanin' mso-bidi-language: FA mso-ansi-language: EN-US" dir="ltr">P</span><span dir="rtl"></span><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ansi-language: EN-US mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri"><span dir="rtl"></span>) و (06/0= </span><span style="FONT-FAMILY: 'Calibri','sans-serif' mso-bidi-font-family: 'B Nazanin' mso-bidi-language: FA mso-ansi-language: EN-US" dir="ltr">P</span><span dir="rtl"></span><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ansi-language: EN-US mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri"><span dir="rtl"></span>) و تفاوت معنی داری بین دو گروه دیده نشد. متغیرهای فوق در لیکن پلان رتیکولر و اروزیو نیز تفاوت معنی داری نداشت. (2/0= </span><span style="FONT-FAMILY: 'Calibri','sans-serif' mso-bidi-font-family: 'B Nazanin' mso-bidi-language: FA mso-ansi-language: EN-US" dir="ltr">P</span><span dir="rtl"></span><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ansi-language: EN-US mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri"><span dir="rtl"></span>)</span></font></h5><h5 style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ansi-language: EN-US mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri"></span> </h5><h5 style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ansi-language: EN-US mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri"><span lang="FA" style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US mso-ascii-font-family: 'Times New Roman Bold' mso-hansi-font-family: 'Times New Roman Bold'" dir="rtl"><font size="2">نتیجه گیری</font></span></span><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ansi-language: EN-US mso-ascii-font-family: Calibri mso-hansi-font-family: Calibri"><span lang="FA" style="FONT-FAMILY: 'B Nazanin' FONT-SIZE: 12pt mso-bidi-language: FA mso-fareast-font-family: 'Times New Roman' mso-ansi-language: EN-US mso-fareast-language: EN-US mso-ascii-font-family: 'Times New Roman Bold' mso-hansi-font-family: 'Times New Roman Bold'" dir="rtl"></span></span></h5><h5 style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><h5 style="TEXT-JUSTIFY: kashida TEXT-ALIGN: justify TEXT-KASHIDA: 0% MARGIN: 0in 0in 0pt unicode-bidi: embed DIRECTION: rtl" dir="rtl"><font size="2"><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA mso-ascii-font-family: 'Times New Roman Bold' mso-hansi-font-family: 'Times New Roman Bold'">به نظر می رسد تغییرات </span><font face="Times New Roman"><span style="mso-bidi-language: FA mso-ansi-language: EN-US" dir="ltr">IFN-δ</span><span dir="rtl"></span><span lang="FA" style="mso-bidi-language: FA mso-ansi-language: EN-US"><span dir="rtl"></span> و </span><span style="mso-bidi-language: FA mso-ansi-language: EN-US" dir="ltr">IL-4</span><span dir="rtl"></span></font><span lang="FA" style="FONT-FAMILY: 'B Nazanin' mso-bidi-language: FA"><span dir="rtl"></span> بزاقی نقشی در پاتولوژی لیکن پلان دهانی ندارد.<p></p></span></font></h5></h5></p></span></h5> <p align="left"> <strong> Abstract: </strong></p><p align="left"> <strong> </strong></p><p align="left"> <strong> Background and Aim </strong>: Saliva levels of IL-4 and IFN gamma have been reported to show discrepancies in patients with Oral Lichen Planus (OLP). The purpose of this study was to assess the saliva levels of these markers with the aim to facilitate the diagnosis and understanding of the pathogenesis of Lichen Planus. <strong></strong></p><p align="left"> <strong> Materials and Methods </strong>: This Case-control study was conducted on 84 samples consisting 30 patients with (OLP) and 54 healthy samples who showed no mucosal lesions on clinical examination. The saliva specimens were analyzed by ELIZA test for evaluation of IL4 And IFN γ levels. Data were analyzed by Mann-U-Whitney test, Spearman and Pearson coefficient tests. <strong></strong></p><p align="left"> <strong> Results </strong>: The saliva levels of IFN-gamma in samples with Lichen Planus was 4.48 + 4.3 compared to 3.54 + 2.7 in healthy samples. The IL-4 alevels were found to be 3.28 +11.07 in patients with Lichen Planus whereas in healthy subjects it was reported to be 2.86 + 6.3. No significant differences were found between the levels of IFN gamma and IL-4 in patients with (OLP) compared to control group. (P = 0.8) (P = 0.06) There is not any differences between reticular and erosive form of OLP in IL-4 and IFN γ levels. (P = 0.2) </p><p align="left"> <strong> Conclusion </strong>: Our findings indicate that these two factors are not involved in pathogenesis of lichen planus, however but more studies. are recommended. </p><p align="left">  </p> لیکن پلان دهانی ،اینترلوکین-4 ،اینترفرون گاما Oral lichen planus, Interlukin-4, Interferon γ. 38 42 http://jrds.ir/browse.php?a_code=A-10-102-2&slc_lang=fa&sid=1 Nafarzadeh SH شیما نفرزاده shima_nafar2004@yahoo.com 10031947532846004039 10031947532846004039 Yes Mostafazadeh A امراله مصطفی زاده 10031947532846004040 10031947532846004040 No Bijani A علی بیژنی 10031947532846004041 10031947532846004041 No Seddigh M محسن صدیق 10031947532846004042 10031947532846004042 No